Chua HC - Search Results

1

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.

Schott K, Usher SG, Serra O, Carnevale V, Pless SA, Chua HC. Schott K, et al. Among authors: chua hc. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2401591121. doi: 10.1073/pnas.2401591121. Epub 2024 May 24. Proc Natl Acad Sci U S A. 2024. PMID: 38787877 Free PMC article.

2

Structure of the human sodium leak channel NALCN.

Kschonsak M, Chua HC, Noland CL, Weidling C, Clairfeuille T, Bahlke OØ, Ameen AO, Li ZR, Arthur CP, Ciferri C, Pless SA, Payandeh J. Kschonsak M, et al. Among authors: chua hc. Nature. 2020 Nov;587(7833):313-318. doi: 10.1038/s41586-020-2570-8. Epub 2020 Jul 22. Nature. 2020. PMID: 32698188

3

Structural architecture of the human NALCN channelosome.

Kschonsak M, Chua HC, Weidling C, Chakouri N, Noland CL, Schott K, Chang T, Tam C, Patel N, Arthur CP, Leitner A, Ben-Johny M, Ciferri C, Pless SA, Payandeh J. Kschonsak M, et al. Among authors: chua hc. Nature. 2022 Mar;603(7899):180-186. doi: 10.1038/s41586-021-04313-5. Epub 2021 Dec 20. Nature. 2022. PMID: 34929720

4

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module.

Schott K, Usher SG, Serra O, Carnevale V, Pless SA, Chua HC. Schott K, et al. Among authors: chua hc. bioRxiv [Preprint]. 2024 Jan 28:2023.04.12.536537. doi: 10.1101/2023.04.12.536537. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2401591121. doi: 10.1073/pnas.2401591121. PMID: 38328210 Free PMC article. Updated. Preprint.

5

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

Chua HC, Wulf M, Weidling C, Rasmussen LP, Pless SA. Chua HC, et al. Sci Adv. 2020 Apr 24;6(17):eaaz3154. doi: 10.1126/sciadv.aaz3154. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32494638 Free PMC article.

6

Structure-guided unlocking of Na_X reveals a non-selective tetrodotoxin-sensitive cation channel.

Noland CL, Chua HC, Kschonsak M, Heusser SA, Braun N, Chang T, Tam C, Tang J, Arthur CP, Ciferri C, Pless SA, Payandeh J. Noland CL, et al. Among authors: chua hc. Nat Commun. 2022 Mar 17;13(1):1416. doi: 10.1038/s41467-022-28984-4. Nat Commun. 2022. PMID: 35301303 Free PMC article.

7

The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons.

Jehasse K, Massotte L, Hartmann S, Vitello R, Ringlet S, Vitello M, Chua HC, Pless SA, Engel D, Liégeois JF, Lakaye B, Roeper J, Seutin V. Jehasse K, et al. Among authors: chua hc. Neuropharmacology. 2021 Oct 1;197:108722. doi: 10.1016/j.neuropharm.2021.108722. Epub 2021 Jul 15. Neuropharmacology. 2021. PMID: 34273387 Free article.

8

Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing.

Khoo KK, Galleano I, Gasparri F, Wieneke R, Harms H, Poulsen MH, Chua HC, Wulf M, Tampé R, Pless SA. Khoo KK, et al. Among authors: chua hc. Nat Commun. 2020 May 8;11(1):2284. doi: 10.1038/s41467-020-16208-6. Nat Commun. 2020. PMID: 32385250 Free PMC article.

9

Unexplained cardiac arrest: a tale of conflicting interpretations of KCNQ1 genetic test results.

Chua HC, Servatius H, Asatryan B, Schaller A, Rieubland C, Noti F, Seiler J, Roten L, Baldinger SH, Tanner H, Fuhrer J, Haeberlin A, Lam A, Pless SA, Medeiros-Domingo A. Chua HC, et al. Clin Res Cardiol. 2018 Aug;107(8):670-678. doi: 10.1007/s00392-018-1233-3. Epub 2018 Mar 26. Clin Res Cardiol. 2018. PMID: 29582136 Free article.

10

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.

Chua HC, Christensen ET, Hoestgaard-Jensen K, Hartiadi LY, Ramzan I, Jensen AA, Absalom NL, Chebib M. Chua HC, et al. PLoS One. 2016 Jun 22;11(6):e0157700. doi: 10.1371/journal.pone.0157700. eCollection 2016. PLoS One. 2016. PMID: 27332705 Free PMC article.

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