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Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Park KS, Xiong Y, Yim H, Velez J, Babault N, Kumar P, Liu J, Jin J. Park KS, et al. Among authors: velez j. J Med Chem. 2022 Aug 11;65(15):10506-10522. doi: 10.1021/acs.jmedchem.2c00652. Epub 2022 Jun 28. J Med Chem. 2022. PMID: 35763668 Free PMC article.
Discovery of the First-in-Class G9a/GLP PROTAC Degrader.
Velez J, Han Y, Yim H, Yang P, Deng Z, Park KS, Kabir M, Kaniskan HÜ, Xiong Y, Jin J. Velez J, et al. J Med Chem. 2024 Apr 25;67(8):6397-6409. doi: 10.1021/acs.jmedchem.3c02394. Epub 2024 Apr 11. J Med Chem. 2024. PMID: 38602846
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.
Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Wei J, et al. Among authors: velez j. J Am Chem Soc. 2021 Sep 22;143(37):15073-15083. doi: 10.1021/jacs.1c04841. Epub 2021 Sep 14. J Am Chem Soc. 2021. PMID: 34520194 Free PMC article.
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Xie L, Sheehy RN, Xiong Y, Muneer A, Wrobel JA, Park KS, Velez J, Liu J, Luo YJ, Li YD, Quintanilla L, Li Y, Xu C, Deshmukh M, Wen Z, Jin J, Song J, Chen X. Xie L, et al. Among authors: velez j. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297491. doi: 10.1101/2023.10.25.23297491. medRxiv. 2023. PMID: 37961307 Free PMC article. Preprint.
538 results