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Page 1
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.
Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Verbeck A, Galasso G, Lee SM, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, Teunissen CE, Sato C, Karch CM. Iyer AK, et al. Among authors: temple s. medRxiv [Preprint]. 2024 May 16:2024.05.15.24307444. doi: 10.1101/2024.05.15.24307444. medRxiv. 2024. PMID: 38798451 Free PMC article. Preprint.
Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling.
Minaya MA, Mahali S, Iyer AK, Eteleeb AM, Martinez R, Huang G, Budde J, Temple S, Nana AL, Seeley WW, Spina S, Grinberg LT, Harari O, Karch CM. Minaya MA, et al. Among authors: temple s. Front Mol Biosci. 2023 Feb 9;10:1051494. doi: 10.3389/fmolb.2023.1051494. eCollection 2023. Front Mol Biosci. 2023. PMID: 36845551 Free PMC article.
Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.
Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, Miller M, Baron H, Sandhof CA, Silva MC, Haggarty SJ, Karch CM, Geschwind DH, Goate AM, Temple S. Bertucci T, et al. Among authors: temple s. bioRxiv [Preprint]. 2023 Jul 11:2023.07.11.548571. doi: 10.1101/2023.07.11.548571. bioRxiv. 2023. PMID: 37503195 Free PMC article. Preprint.
Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons.
D'Brant L, Rugenstein N, Na SK, Miller MJ, Czajka TF, Trudeau N, Fitz E, Tomaszek L, Fisher ES, Mash E, Joy S, Lotz S, Borden S, Stevens K, Goderie SK, Wang Y, Bertucci T, Karch CM, Temple S, Butler DC. D'Brant L, et al. Among authors: temple s. bioRxiv [Preprint]. 2024 Jun 1:2024.05.28.596248. doi: 10.1101/2024.05.28.596248. bioRxiv. 2024. PMID: 38854137 Free PMC article. Preprint.
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, Temple S, Arkin MR, Grinberg LT. Theofilas P, et al. Among authors: temple s. Mol Cell Neurosci. 2024 Sep;130:103954. doi: 10.1016/j.mcn.2024.103954. Epub 2024 Jul 20. Mol Cell Neurosci. 2024. PMID: 39032719
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344 results