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Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases.
Zhang S, Shu H, Zhou J, Rubin-Sigler J, Yang X, Liu Y, Cooper-Knock J, Monte E, Zhu C, Tu S, Li H, Tong M, Ecker JR, Ichida JK, Shen Y, Zeng J, Tsao PS, Snyder MP. Zhang S, et al. Among authors: tu s. bioRxiv [Preprint]. 2024 May 14:2024.05.14.594252. doi: 10.1101/2024.05.14.594252. bioRxiv. 2024. PMID: 38798507 Free PMC article. Preprint.
Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS.
Zhang S, Moll T, Rubin-Sigler J, Tu S, Li S, Yuan E, Liu M, Butt A, Harvey C, Gornall S, Alhalthli E, Shaw A, Souza CDS, Ferraiuolo L, Hornstein E, Shelkovnikova T, van Dijk CH, Timpanaro IS, Kenna KP, Zeng J, Tsao PS, Shaw PJ, Ichida JK, Cooper-Knock J, Snyder MP. Zhang S, et al. Among authors: tu s. medRxiv [Preprint]. 2024 Apr 1:2024.03.30.24305115. doi: 10.1101/2024.03.30.24305115. medRxiv. 2024. PMID: 38633814 Free PMC article. Preprint.
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK. Linares GR, et al. Among authors: tu s. Cell Stem Cell. 2023 Feb 2;30(2):171-187.e14. doi: 10.1016/j.stem.2023.01.005. Cell Stem Cell. 2023. PMID: 36736291 Free PMC article.
Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients.
Cheng TC, Hung MC, Wang LH, Tu SH, Wu CH, Yen Y, Chen CL, Whang-Peng J, Lee WJ, Liao YC, Lee YC, Pan MH, Lin HK, Tzeng HE, Guo P, Chu CY, Chen LC, Ho YS. Cheng TC, et al. Among authors: tu sh. Biomark Res. 2025 Jan 9;13(1):7. doi: 10.1186/s40364-024-00715-5. Biomark Res. 2025. PMID: 39789599 Free PMC article.
Leveraging Old Hepatitis C Therapies.
Tu SS, Kottilil S, Mattingly TJ 2nd. Tu SS, et al. N Engl J Med. 2024 Dec 28. doi: 10.1056/NEJMp2409842. Online ahead of print. N Engl J Med. 2024. PMID: 39752558 No abstract available.
2,680 results