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Page 1
De novo designed proteins neutralize lethal snake venom toxins.
Vázquez Torres S, Benard Valle M, Mackessy SP, Menzies SK, Casewell NR, Ahmadi S, Burlet NJ, Muratspahić E, Sappington I, Overath MD, Rivera-de-Torre E, Ledergerber J, Laustsen AH, Boddum K, Bera AK, Kang A, Brackenbrough E, Cardoso IA, Crittenden EP, Edge RJ, Decarreau J, Ragotte RJ, Pillai AS, Abedi M, Han HL, Gerben SR, Murray A, Skotheim R, Stuart L, Stewart L, Fryer TJA, Jenkins TP, Baker D. Vázquez Torres S, et al. Among authors: cardoso ia. Nature. 2025 Jan 15. doi: 10.1038/s41586-024-08393-x. Online ahead of print. Nature. 2025. PMID: 39814879
De novo designed proteins neutralize lethal snake venom toxins.
Torres SV, Valle MB, Mackessy SP, Menzies SK, Casewell NR, Ahmadi S, Burlet NJ, Muratspahić E, Sappington I, Overath MD, Rivera-de-Torre E, Ledergerber J, Laustsen AH, Boddum K, Bera AK, Kang A, Brackenbrough E, Cardoso IA, Crittenden EP, Edge RJ, Decarreau J, Ragotte RJ, Pillai AS, Abedi M, Han HL, Gerben SR, Murray A, Skotheim R, Stuart L, Stewart L, Fryer TJA, Jenkins TP, Baker D. Torres SV, et al. Among authors: cardoso ia. Res Sq [Preprint]. 2024 May 17:rs.3.rs-4402792. doi: 10.21203/rs.3.rs-4402792/v1. Res Sq. 2024. Update in: Nature. 2025 Jan 15. doi: 10.1038/s41586-024-08393-x PMID: 38798548 Free PMC article. Updated. Preprint.
Design and Synthesis of Novel 3-Nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis.
Pelizaro BI, Batista JCZ, Portapilla GB, das Neves AR, Silva F, Carvalho DB, Shiguemoto CYK, Pessatto LR, Paredes-Gamero EJ, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, Galvão F, Oliveira KMP, Cassemiro NS, Silva DB, Piranda EM, Arruda CCP, de Albuquerque S, Baroni ACM. Pelizaro BI, et al. Among authors: cardoso ia. J Med Chem. 2024 Feb 22;67(4):2584-2601. doi: 10.1021/acs.jmedchem.3c01745. Epub 2024 Feb 2. J Med Chem. 2024. PMID: 38305199
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming.
Menzies SK, Arinto-Garcia R, Amorim FG, Cardoso IA, Abada C, Crasset T, Durbesson F, Edge RJ, El-Kazzi P, Hall S, Redureau D, Stenner R, Boldrini-França J, Sun H, Roldão A, Alves PM, Harrison RA, Vincentelli R, Berger I, Quinton L, Casewell NR, Schaffitzel C. Menzies SK, et al. Among authors: cardoso ia. Toxins (Basel). 2023 Nov 28;15(12):673. doi: 10.3390/toxins15120673. Toxins (Basel). 2023. PMID: 38133177 Free PMC article.
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
Carvalho DB, Costa PAN, Portapilla GB, das Neves AR, Shiguemoto CYK, Pelizaro BI, Silva F, Piranda EM, Arruda CCP, Gaspari PDM, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, de Albuquerque S, Baroni ACM. Carvalho DB, et al. Among authors: cardoso ia. Eur J Med Chem. 2023 Nov 15;260:115451. doi: 10.1016/j.ejmech.2023.115451. Epub 2023 May 5. Eur J Med Chem. 2023. PMID: 37573209
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J. Hicks KG, et al. Among authors: cardoso ia. Science. 2023 Mar 10;379(6636):996-1003. doi: 10.1126/science.abm3452. Epub 2023 Mar 9. Science. 2023. PMID: 36893255 Free PMC article.
Repurposing of 5-nitrofuran-3,5-disubstituted isoxazoles: A thriving scaffold to antitrypanosomal agents.
Carvalho DB, das Neves AR, Portapilla GB, Soares O, Santos LBB, Oliveira JRS, Vianna LS, Judice WAS, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, de Albuquerque S, Baroni ACM. Carvalho DB, et al. Among authors: cardoso ia. Arch Pharm (Weinheim). 2023 Apr;356(4):e2200472. doi: 10.1002/ardp.202200472. Epub 2022 Dec 19. Arch Pharm (Weinheim). 2023. PMID: 36534890
36 results