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Page 1
Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes.
Zhu S, Waeckel-Énée E, Oshima M, Moser A, Bessard MA, Gdoura A, Roger K, Mode N, Lipecka J, Yilmaz A, Bertocci B, Diana J, Saintpierre B, Guerrera IC, Scharfmann R, Francesconi S, Mauvais FX, van Endert P. Zhu S, et al. Among authors: scharfmann r. iScience. 2024 May 7;27(6):109929. doi: 10.1016/j.isci.2024.109929. eCollection 2024 Jun 21. iScience. 2024. PMID: 38799566 Free PMC article.
Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.
Carré A, Zhou Z, Perez-Hernandez J, Samassa F, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Göransson M, Morales OB, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Carré A, et al. Among authors: scharfmann r. bioRxiv [Preprint]. 2023 Sep 17:2023.09.15.557918. doi: 10.1101/2023.09.15.557918. bioRxiv. 2023. PMID: 37745505 Free PMC article. Preprint.
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Cuozzo F, Viloria K, Shilleh AH, Nasteska D, Frazer-Morris C, Tong J, Jiao Z, Boufersaoui A, Marzullo B, Rosoff DB, Smith HR, Bonner C, Kerr-Conte J, Pattou F, Nano R, Piemonti L, Johnson PRV, Spiers R, Roberts J, Lavery GG, Clark A, Ceresa CDL, Ray DW, Hodson L, Davies AP, Rutter GA, Oshima M, Scharfmann R, Merrins MJ, Akerman I, Tennant DA, Ludwig C, Hodson DJ. Cuozzo F, et al. Among authors: scharfmann r. Cell Rep. 2024 Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11. Cell Rep. 2024. PMID: 38607916 Free PMC article.
Tryptophan metabolism promotes immune evasion in human pancreatic β cells.
Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R. Rachdi L, et al. Among authors: scharfmann r. EBioMedicine. 2023 Sep;95:104740. doi: 10.1016/j.ebiom.2023.104740. Epub 2023 Aug 1. EBioMedicine. 2023. PMID: 37536063 Free PMC article.
Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes.
Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Hendriks AEJ, et al. Diabetes Metab Res Rev. 2024 Feb;40(2):e3777. doi: 10.1002/dmrr.3777. Diabetes Metab Res Rev. 2024. PMID: 38375753
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses.
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Vecchio F, et al. Among authors: scharfmann r. Sci Adv. 2024 Mar 8;10(10):eadl1122. doi: 10.1126/sciadv.adl1122. Epub 2024 Mar 6. Sci Adv. 2024. PMID: 38446892 Free PMC article.
Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses.
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Vecchio F, et al. Among authors: scharfmann r. bioRxiv [Preprint]. 2023 Aug 21:2023.08.19.553954. doi: 10.1101/2023.08.19.553954. bioRxiv. 2023. Update in: Sci Adv. 2024 Mar 8;10(10):eadl1122. doi: 10.1126/sciadv.adl1122 PMID: 37662376 Free PMC article. Updated. Preprint.
Imaging human pancreatic endocrinogenesis during early prenatal life.
Villalba A, Gitton Y, Aiello V, Toupin M, Mazaud-Guittot S, Chédotal A, Scharfmann R. Villalba A, et al. Among authors: scharfmann r. Diabetes. 2024 Nov 27:db240641. doi: 10.2337/db24-0641. Online ahead of print. Diabetes. 2024. PMID: 39602451
Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgün Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H. Siehler J, et al. Among authors: scharfmann r. Nat Metab. 2024 Dec;6(12):2374-2390. doi: 10.1038/s42255-024-01164-y. Epub 2024 Nov 25. Nat Metab. 2024. PMID: 39587340 Free PMC article.
199 results