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Engineered CAR-T cells targeting the non-functional P2X purinoceptor 7 (P2X7) receptor as a novel treatment for ovarian cancer.
Bandara V, Niktaras VM, Willett VJ, Chapman H, Lokman NA, Macpherson AM, Napoli S, Gundsambuu B, Foeng J, Sadlon TJ, Coombs J, McColl SR, Barry SC, Oehler MK, Ricciardelli C. Bandara V, et al. Among authors: coombs j. Clin Transl Immunology. 2024 May 23;13(5):e1512. doi: 10.1002/cti2.1512. eCollection 2024. Clin Transl Immunology. 2024. PMID: 38800555 Free PMC article.
Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7.
Bandara V, Foeng J, Gundsambuu B, Norton TS, Napoli S, McPeake DJ, Tyllis TS, Rohani-Rad E, Abbott C, Mills SJ, Tan LY, Thompson EJ, Willet VM, Nikitaras VJ, Zheng J, Comerford I, Johnson A, Coombs J, Oehler MK, Ricciardelli C, Cowin AJ, Bonder CS, Jensen M, Sadlon TJ, McColl SR, Barry SC. Bandara V, et al. Among authors: coombs j. Nat Commun. 2023 Sep 8;14(1):5546. doi: 10.1038/s41467-023-41338-y. Nat Commun. 2023. PMID: 37684239 Free PMC article.
Inertial Microfluidic Purification of CAR-T-Cell Products.
Elsemary MT, Maritz MF, Smith LE, Warkiani M, Bandara V, Napoli S, Barry SC, Coombs JT, Thierry B. Elsemary MT, et al. Adv Biol (Weinh). 2022 Jan;6(1):e2101018. doi: 10.1002/adbi.202101018. Epub 2021 Dec 8. Adv Biol (Weinh). 2022. PMID: 34881810
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, Condon ND, Emming S, Crawford J, Lawrence GMEP, Coombs JR, Lefevre JG, Bajracharya R, Lahoud MH, Yap AS, Hamilton N, Stehbens SJ, Kagan JC, Ariotti N, Burgener SS, Schroder K. Holley CL, et al. Among authors: coombs jr. Nat Immunol. 2025 Jan;26(1):42-52. doi: 10.1038/s41590-024-02024-3. Epub 2024 Dec 4. Nat Immunol. 2025. PMID: 39633178 Free PMC article.
Promiscuous potato: elucidating genetic identity and the complex genetic relationships of a cultivated potato germplasm collection.
Anglin NL, Chavez O, Soto-Torres J, Gomez R, Panta A, Vollmer R, Durand M, Meza C, Azevedo V, Manrique-Carpintero NC, Kauth P, Coombs JJ, Douches DS, Ellis D. Anglin NL, et al. Among authors: coombs jj. Front Plant Sci. 2024 Jul 1;15:1341788. doi: 10.3389/fpls.2024.1341788. eCollection 2024. Front Plant Sci. 2024. PMID: 39011311 Free PMC article.
Genotype-by-environment interactions and local adaptation shape selection in the US National Chip Processing Trial.
Agha HI, Endelman JB, Chitwood-Brown J, Clough M, Coombs J, De Jong WS, Douches DS, Higgins CR, Holm DG, Novy R, Resende MFR, Sathuvalli V, Thompson AL, Yencho GC, Zotarelli L, Shannon LM. Agha HI, et al. Among authors: coombs j. Theor Appl Genet. 2024 Apr 10;137(5):99. doi: 10.1007/s00122-024-04610-3. Theor Appl Genet. 2024. PMID: 38598016 Free PMC article.
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657
280 results