Zheng G - Search Results

1

Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs.

Bricelj A, Dora Ng YL, Gobec M, Kuchta R, Hu W, Javornik Š, Rožič M, Gütschow M, Zheng G, Krönke J, Steinebach C, Sosič I. Bricelj A, et al. Among authors: zheng g. Chemistry. 2024 Aug 12;30(45):e202400430. doi: 10.1002/chem.202400430. Epub 2024 Jul 25. Chemistry. 2024. PMID: 38818652

2

Targeted degradation of specific TEAD paralogs by small molecule degraders.

Chen H, Gridnev A, Schlamowitz N, Hu W, Dey K, Zheng G, Misra JR. Chen H, et al. Among authors: zheng g. Heliyon. 2024 Sep 14;10(18):e37829. doi: 10.1016/j.heliyon.2024.e37829. eCollection 2024 Sep 30. Heliyon. 2024. PMID: 39328531 Free PMC article.

3

Piperlongumine conjugates induce targeted protein degradation.

Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D. Pei J, et al. Among authors: zheng g. Cell Chem Biol. 2023 Feb 16;30(2):203-213.e17. doi: 10.1016/j.chembiol.2023.01.004. Epub 2023 Feb 6. Cell Chem Biol. 2023. PMID: 36750097 Free PMC article.

4

Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells.

Jia Y, Han L, Ramage CL, Wang Z, Weng CC, Yang L, Colla S, Ma H, Zhang W, Andreeff M, Daver N, Jain N, Pemmaraju N, Bhalla K, Mustjoki S, Zhang P, Zheng G, Zhou D, Zhang Q, Konopleva M. Jia Y, et al. Among authors: zheng g. Haematologica. 2023 Oct 1;108(10):2626-2638. doi: 10.3324/haematol.2022.281915. Haematologica. 2023. PMID: 37078252 Free PMC article.

5

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer.

Khan S, Cao L, Wiegand J, Zhang P, Zajac-Kaye M, Kaye FJ, Zheng G, Zhou D. Khan S, et al. Among authors: zheng g. bioRxiv [Preprint]. 2024 Mar 1:2024.02.27.582353. doi: 10.1101/2024.02.27.582353. bioRxiv. 2024. Update in: Cells. 2024 Mar 17;13(6):528. doi: 10.3390/cells13060528 PMID: 38464204 Free PMC article. Updated. Preprint.

6

A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR.

Han S, Tushoski-Alemán GW, Zhang P, Zheng G, Zhou D, Huo Z, Licht J, George TJ, Allegra C, Trevino JG, Hughes SJ. Han S, et al. Among authors: zheng g. Neoplasia. 2025 Jan;59:101070. doi: 10.1016/j.neo.2024.101070. Epub 2024 Nov 14. Neoplasia. 2025. PMID: 39541736 Free PMC article.

7

Patent landscape of small molecule inhibitors of METTL3 (2020-present).

Wu Z, Smith AR, Qian Z, Zheng G. Wu Z, et al. Among authors: zheng g. Expert Opin Ther Pat. 2024 Dec 26:1-16. doi: 10.1080/13543776.2024.2447056. Online ahead of print. Expert Opin Ther Pat. 2024. PMID: 39721070 Review.

8

Powering up targeted protein degradation through active and passive tumour-targeting strategies: Current and future scopes.

Venkatesan J, Murugan D, Lakshminarayanan K, Smith AR, Vasanthakumari Thirumalaiswamy H, Kandhasamy H, Zender B, Zheng G, Rangasamy L. Venkatesan J, et al. Among authors: zheng g. Pharmacol Ther. 2024 Nov;263:108725. doi: 10.1016/j.pharmthera.2024.108725. Epub 2024 Sep 24. Pharmacol Ther. 2024. PMID: 39322067 Review.

9

Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis.

Jaiswal A, Jaiswal A, Williamson EA, Gelfond J, Zheng G, Zhou D, Hromas R. Jaiswal A, et al. Among authors: zheng g. Cancer Chemother Pharmacol. 2023 Jan;91(1):89-95. doi: 10.1007/s00280-022-04490-8. Epub 2022 Nov 8. Cancer Chemother Pharmacol. 2023. PMID: 36346454 Free PMC article.

10

Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.

Gong S, Maegawa S, Yang Y, Gopalakrishnan V, Zheng G, Cheng D. Gong S, et al. Among authors: zheng g. Biochem J. 2020 Nov 27;478(2):389-406. doi: 10.1042/BCJ20200411. Online ahead of print. Biochem J. 2020. PMID: 33245113 Free PMC article.

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