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Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma.
Davies N, Francis T, Oldreive C, Azam M, Wilson J, Byrd PJ, Burley M, Sharma-Oates A, Keane P, Alatawi S, Higgs MR, Rudzki Z, Ibrahim M, Perry T, Agathanggelou A, Hewitt AM, Smith E, Bonifer C, O'Connor M, Forment JV, Murray PG, Fennell E, Kelly G, Chang C, Stewart GS, Stankovic T, Kwok M, Taylor AM. Davies N, et al. Among authors: keane p. Haematologica. 2024 Dec 1;109(12):3989-4006. doi: 10.3324/haematol.2023.284404. Haematologica. 2024. PMID: 38841800 Free PMC article.
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth.
Kellaway SG, Potluri S, Keane P, Blair HJ, Ames L, Worker A, Chin PS, Ptasinska A, Derevyanko PK, Adamo A, Coleman DJL, Khan N, Assi SA, Krippner-Heidenreich A, Raghavan M, Cockerill PN, Heidenreich O, Bonifer C. Kellaway SG, et al. Among authors: keane p. Nat Commun. 2024 Feb 14;15(1):1359. doi: 10.1038/s41467-024-45691-4. Nat Commun. 2024. PMID: 38355578 Free PMC article.
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