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Asciminib stands out as the superior tyrosine kinase inhibitor to combine with anti-CD20 monoclonal antibodies for the treatment of CD20+ Philadelphia-positive B-cell precursor acute lymphoblastic leukemia in preclinical models.
Domka K, Dąbkowska A, Janowska M, Urbańska Z, Pastorczak A, Winiarska M, Fidyt K, Lachota M, Patkowska E, Sędek Ł, Perkowski B, Hunia J, Jakubowska J, Krzymieniewska B, Lech-Marańda E, Młynarski W, Szczepański T, Firczuk M. Domka K, et al. Haematologica. 2024 Nov 1;109(11):3520-3532. doi: 10.3324/haematol.2023.284853. Haematologica. 2024. PMID: 38841802 Free PMC article.
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.
Fidyt K, Pastorczak A, Cyran J, Crump NT, Goral A, Madzio J, Muchowicz A, Poprzeczko M, Domka K, Komorowski L, Winiarska M, Harman JR, Siudakowska K, Graczyk-Jarzynka A, Patkowska E, Lech-Maranda E, Mlynarski W, Golab J, Milne TA, Firczuk M. Fidyt K, et al. Among authors: domka k. Oncogene. 2022 Mar;41(11):1600-1609. doi: 10.1038/s41388-022-02196-y. Epub 2022 Jan 28. Oncogene. 2022. PMID: 35091682 Free PMC article.
Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia.
Pastorczak A, Domka K, Fidyt K, Poprzeczko M, Firczuk M. Pastorczak A, et al. Among authors: domka k. Cancers (Basel). 2021 Mar 26;13(7):1536. doi: 10.3390/cancers13071536. Cancers (Basel). 2021. PMID: 33810515 Free PMC article. Review.