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Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex.
Williams BG, King LDW, Pulido D, Quinkert D, Lias AM, Silk SE, Ragotte RJ, Davies H, Barrett JR, McHugh K, Rigby CA, Alanine DGW, Barfod L, Shea MW, Cowley LA, Dabbs RA, Pattinson DJ, Douglas AD, Lyth OR, Illingworth JJ, Jin J, Carnrot C, Kotraiah V, Christen JM, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Skinner K, Miura K, Long CA, Higgins MK, Draper SJ. Williams BG, et al. Among authors: macgill rs. Nat Commun. 2024 Jun 7;15(1):4857. doi: 10.1038/s41467-024-48721-3. Nat Commun. 2024. PMID: 38849365 Free PMC article.
Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine.
Chaudhury S, MacGill RS, Early AM, Bolton JS, King CR, Locke E, Pierson T, Wirth DF, Neafsey DE, Bergmann-Leitner ES. Chaudhury S, et al. Among authors: macgill rs. Vaccine. 2021 Feb 5;39(6):968-975. doi: 10.1016/j.vaccine.2020.12.055. Epub 2021 Jan 9. Vaccine. 2021. PMID: 33431225 Free article.
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum.
Beutler N, Pholcharee T, Oyen D, Flores-Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W, Locke E, Regules JA, Dutta S, Emerling D, Early AM, Neafsey DE, Winzeler EA, King CR, Zavala F, Burton DR, Wilson IA, Rogers TF. Beutler N, et al. Among authors: macgill rs. PLoS Pathog. 2022 Mar 28;18(3):e1010409. doi: 10.1371/journal.ppat.1010409. eCollection 2022 Mar. PLoS Pathog. 2022. PMID: 35344575 Free PMC article.
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses.
McLeod B, Mabrouk MT, Miura K, Ravichandran R, Kephart S, Hailemariam S, Pham TP, Semesi A, Kucharska I, Kundu P, Huang WC, Johnson M, Blackstone A, Pettie D, Murphy M, Kraft JC, Leaf EM, Jiao Y, van de Vegte-Bolmer M, van Gemert GJ, Ramjith J, King CR, MacGill RS, Wu Y, Lee KK, Jore MM, King NP, Lovell JF, Julien JP. McLeod B, et al. Among authors: macgill rs. Immunity. 2022 Sep 13;55(9):1680-1692.e8. doi: 10.1016/j.immuni.2022.07.015. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977542 Free PMC article.
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.
Martin GM, Torres JL, Pholcharee T, Oyen D, Flores-Garcia Y, Gibson G, Moskovitz R, Beutler N, Jung DD, Copps J, Lee WH, Gonzalez-Paez G, Emerling D, MacGill RS, Locke E, King CR, Zavala F, Wilson IA, Ward AB. Martin GM, et al. Among authors: macgill rs. Nat Commun. 2023 Jul 28;14(1):4546. doi: 10.1038/s41467-023-40151-x. Nat Commun. 2023. PMID: 37507365 Free PMC article.
A candidate antibody drug for prevention of malaria.
Williams KL, Guerrero S, Flores-Garcia Y, Kim D, Williamson KS, Siska C, Smidt P, Jepson SZ, Li K, Dennison SM, Mathis-Torres S, Chen X, Wille-Reece U, MacGill RS, Walker M, Jongert E, King CR, Ockenhouse C, Glanville J, Moon JE, Regules JA, Tan YC, Cavet G, Lippow SM, Robinson WH, Dutta S, Tomaras GD, Zavala F, Ketchem RR, Emerling DE. Williams KL, et al. Among authors: macgill rs. Nat Med. 2024 Jan;30(1):117-129. doi: 10.1038/s41591-023-02659-z. Epub 2024 Jan 2. Nat Med. 2024. PMID: 38167935 Free PMC article.
Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies.
King LDW, Pulido D, Barrett JR, Davies H, Quinkert D, Lias AM, Silk SE, Pattinson DJ, Diouf A, Williams BG, McHugh K, Rodrigues A, Rigby CA, Strazza V, Suurbaar J, Rees-Spear C, Dabbs RA, Ishizuka AS, Zhou Y, Gupta G, Jin J, Li Y, Carnrot C, Minassian AM, Campeotto I, Fleishman SJ, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Long CA, Miura K, Ashfield R, Skinner K, Howarth MR, Biswas S, Draper SJ. King LDW, et al. Among authors: macgill rs. Cell Rep Med. 2024 Jul 16;5(7):101654. doi: 10.1016/j.xcrm.2024.101654. Cell Rep Med. 2024. PMID: 39019011 Free PMC article.
35 results