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ETD001: A novel inhaled ENaC blocker with an extended duration of action in vivo.
Danahay H, McCarthy C, Schofield T, Fox R, Charlton H, Lilley S, Sabater J, Salathe M, Baumlin N, Collingwood SP, Gosling M. Danahay H, et al. Among authors: charlton h. J Cyst Fibros. 2024 Jun 7:S1569-1993(24)00081-X. doi: 10.1016/j.jcf.2024.06.002. Online ahead of print. J Cyst Fibros. 2024. PMID: 38851923 Free article.
Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction.
Danahay H, Fox R, Lilley S, Charlton H, Adley K, Christie L, Ansari E, Ehre C, Flen A, Tuvim MJ, Dickey BF, Williams C, Beaudoin S, Collingwood SP, Gosling M. Danahay H, et al. Among authors: charlton h. FASEB Bioadv. 2020 Jul 1;2(8):464-477. doi: 10.1096/fba.2020-00035. eCollection 2020 Aug. FASEB Bioadv. 2020. PMID: 32821878 Free PMC article.
Optimisation of a novel series of ENaC inhibitors, leading to the selection of the long-acting inhaled clinical candidate ETD001, a potential new treatment for cystic fibrosis.
Danahay H, Gosling M, Fox R, Lilley S, Charlton H, Hargrave JD, Schofield TB, Hay DA, Went N, McMahon P, Marlin F, Scott J, Vile J, Hewison S, Ellam S, Brown S, Sabater J, Kennet G, Lightowler S, Collingwood SP. Danahay H, et al. Among authors: charlton h. Eur J Med Chem. 2025 Jan 15;282:117040. doi: 10.1016/j.ejmech.2024.117040. Epub 2024 Nov 8. Eur J Med Chem. 2025. PMID: 39561495 Free article.
135 results