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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.
Linetsky M, Bondelid KS, Losovskiy S, Gabyak V, Rullo MJ, Stiadle TI, Munjapara V, Saxena P, Ma D, Cheng YS, Howes AM, Udeigwe E, Salomon RG. Linetsky M, et al. Among authors: howes am. Chem Res Toxicol. 2018 Aug 20;31(8):666-679. doi: 10.1021/acs.chemrestox.8b00028. Epub 2018 Jul 9. Chem Res Toxicol. 2018. PMID: 29883119 Free PMC article.
4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids.
Wang H, Linetsky M, Guo J, Choi J, Hong L, Chamberlain AS, Howell SJ, Howes AM, Salomon RG. Wang H, et al. Among authors: howes am. Chem Res Toxicol. 2015 May 18;28(5):967-77. doi: 10.1021/acs.chemrestox.5b00001. Epub 2015 Apr 2. Chem Res Toxicol. 2015. PMID: 25793308 Free PMC article.