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Page 1
Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma.
Wu L, Zhao Z, Shin YJ, Yin Y, Raju A, Vaiyapuri TS, Idzham K, Son M, Lee Y, Sa JK, Chua JYH, Unal B, Zhai Y, Fan W, Huang L, Hu H, Gunaratne J, Nam DH, Jiang T, Tergaonkar V. Wu L, et al. Among authors: chua jyh. Nat Cell Biol. 2024 Jun;26(6):1003-1018. doi: 10.1038/s41556-024-01428-5. Epub 2024 Jun 10. Nat Cell Biol. 2024. PMID: 38858501 Free PMC article.
Genome-wide screens identify specific drivers of mutant hTERT promoters.
Shanmugam R, Ozturk MB, Low JL, Akincilar SC, Chua JYH, Thangavelu MT, Periyasamy G, DasGupta R, Tergaonkar V. Shanmugam R, et al. Among authors: chua jyh. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2105171119. doi: 10.1073/pnas.2105171119. Proc Natl Acad Sci U S A. 2022. PMID: 35027447 Free PMC article.
Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer.
Akıncılar SC, Chua JYH, Ng QF, Chan CHT, Eslami-S Z, Chen K, Low JL, Arumugam S, Aswad L, Chua C, Tan IB, DasGupta R, Fullwood MJ, Tergaonkar V. Akıncılar SC, et al. Among authors: chua jyh. Nucleic Acids Res. 2023 Jan 11;51(1):1-16. doi: 10.1093/nar/gkac479. Nucleic Acids Res. 2023. PMID: 35697349 Free PMC article.
Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers.
Shanmugam R, Majee P, Shi W, Ozturk MB, Vaiyapuri TS, Idzham K, Raju A, Shin SH, Fidan K, Low JL, Chua JYH, Kong YC, Qi OY, Tan E, Chok AY, Seow-En I, Wee I, Macalinao DC, Chong DQ, Chang HY, Lee F, Leow WQ, Murata-Hori M, Xiaoqian Z, Shumei C, Tan CSH, Dasgupta R, Tan IB, Tergaonkar V. Shanmugam R, et al. Among authors: chua jyh. Cancer Discov. 2024 Oct 4;14(10):1940-1963. doi: 10.1158/2159-8290.CD-23-1379. Cancer Discov. 2024. PMID: 38885349 Free PMC article.
GATA4 downregulation enhances CCL20-mediated immunosuppression in hepatocellular carcinoma.
Nasir NJM, Chuah S, Shuen T, Prawira A, Ba R, Lim MC, Chua J, Nguyen PHD, Lim CJ, Wasser M, Hazirah SN, Lim TKH, Leow WQ, Loh TJ, Wan WK, Pang YH, Soon G, Cheow PC, Kam JH, Iyer S, Kow A, Dan YY, Bonney GK, Chung A, Goh BKP, Chow PKH, Albani S, Zhai W, Ouyang JF, Toh HC, Chew V. Nasir NJM, et al. Hepatol Commun. 2024 Aug 19;8(9):e0508. doi: 10.1097/HC9.0000000000000508. eCollection 2024 Sep 1. Hepatol Commun. 2024. PMID: 39167427 Free PMC article.