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Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.
Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Böll S, Bläsius K, Düsterhöft S, Jahr H, Merkel R, Leube R, Babendreyer A, Ludwig A. Grannemann C, et al. Among authors: ludwig a. Biomater Adv. 2023 Sep;152:213516. doi: 10.1016/j.bioadv.2023.213516. Epub 2023 Jun 12. Biomater Adv. 2023. PMID: 37348330 Free article.
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation.
Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, Schwarz N, Denecke B, Jahr H, Zimmermann P, Dreymueller D, Ludwig A. Pasqualon T, et al. Among authors: ludwig a. Cell Mol Life Sci. 2015 Oct;72(19):3783-801. doi: 10.1007/s00018-015-1912-4. Epub 2015 Apr 26. Cell Mol Life Sci. 2015. PMID: 25912030 Free PMC article.
Status update on iRhom and ADAM17: It's still complicated.
Düsterhöft S, Babendreyer A, Giese AA, Flasshove C, Ludwig A. Düsterhöft S, et al. Among authors: ludwig a. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1567-1583. doi: 10.1016/j.bbamcr.2019.06.017. Epub 2019 Jul 19. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31330158 Free article. Review.
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. Seifert A, et al. Among authors: ludwig a. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. Cell Mol Life Sci. 2021. PMID: 32372373 Free PMC article.
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity.
Kahveci-Türköz S, Bläsius K, Wozniak J, Rinkens C, Seifert A, Kasparek P, Ohm H, Oltzen S, Nieszporek M, Schwarz N, Babendreyer A, Preisinger C, Sedlacek R, Ludwig A, Düsterhöft S. Kahveci-Türköz S, et al. Among authors: ludwig a. Cell Mol Life Sci. 2023 Apr 29;80(5):135. doi: 10.1007/s00018-023-04783-y. Cell Mol Life Sci. 2023. PMID: 37119365 Free PMC article.
1,318 results