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A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties.
Laghezza A, Cerchia C, Genovese M, Montanari R, Capelli D, Wackerlig J, Simic S, Falbo E, Pecora L, Leuci R, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Sudeep CA, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: tortorella p. Eur J Med Chem. 2024 Sep 5;275:116567. doi: 10.1016/j.ejmech.2024.116567. Epub 2024 Jun 9. Eur J Med Chem. 2024. PMID: 38865743
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C. Folgueras AR, et al. Among authors: tortorella p. J Biol Chem. 2018 Jul 27;293(30):11968-11969. doi: 10.1074/jbc.AAC118.004703. J Biol Chem. 2018. PMID: 30054293 Free PMC article. No abstract available.
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.
Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Conte-Camerino D, De Luca A, Liantonio A. Carbonara G, et al. Among authors: tortorella p. Farmaco. 2001 Oct;56(10):749-54. doi: 10.1016/s0014-827x(01)01127-2. Farmaco. 2001. PMID: 11718267
126 results