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Advancing surgical instrument safety: A screen of oxidative and alkaline prion decontaminants using real-time quaking-induced conversion with prion-coated steel beads as surgical instrument mimetic.
Heinzer D, Avar M, Pfammatter M, Moos R, Schwarz P, Buhmann MT, Kuhn B, Mauerhofer S, Rosenberg U, Aguzzi A, Hornemann S. Heinzer D, et al. PLoS One. 2024 Jun 13;19(6):e0304603. doi: 10.1371/journal.pone.0304603. eCollection 2024. PLoS One. 2024. PMID: 38870196 Free PMC article.
Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties.
Harel I, Chen YR, Ziv I, Singh PP, Heinzer D, Navarro Negredo P, Goshtchevsky U, Wang W, Astre G, Moses E, McKay A, Machado BE, Hebestreit K, Yin S, Sánchez Alvarado A, Jarosz DF, Brunet A. Harel I, et al. Among authors: heinzer d. Cell Rep. 2024 Jun 25;43(6):112787. doi: 10.1016/j.celrep.2023.112787. Epub 2024 May 28. Cell Rep. 2024. PMID: 38810650 Free PMC article.
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.
Avar M, Heinzer D, Thackray AM, Liu Y, Hruska-Plochan M, Sellitto S, Schaper E, Pease DP, Yin JA, Lakkaraju AK, Emmenegger M, Losa M, Chincisan A, Hornemann S, Polymenidou M, Bujdoso R, Aguzzi A. Avar M, et al. Among authors: heinzer d. EMBO J. 2022 Dec 1;41(23):e112338. doi: 10.15252/embj.2022112338. Epub 2022 Oct 18. EMBO J. 2022. PMID: 36254605 Free PMC article.
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
Heinzer D, Avar M, Pease DP, Dhingra A, Yin JA, Schaper E, Doğançay B, Emmenegger M, Spinelli A, Maggi K, Chincisan A, Mead S, Hornemann S, Heutink P, Aguzzi A. Heinzer D, et al. PLoS Pathog. 2021 Oct 27;17(10):e1010013. doi: 10.1371/journal.ppat.1010013. eCollection 2021 Oct. PLoS Pathog. 2021. PMID: 34705895 Free PMC article.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, Reimann R, Häsler LM, Herling TW, Matharu NS, Landeck N, Luk K, Melki R, Kahle PJ, Hornemann S, Knowles TPJ, Cookson MR, Polymenidou M, Jucker M, Aguzzi A. Emmenegger M, et al. Among authors: heinzer d. EMBO Mol Med. 2021 Sep 7;13(9):e14745. doi: 10.15252/emmm.202114745. Epub 2021 Jul 26. EMBO Mol Med. 2021. PMID: 34309222 Free PMC article.
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botía JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, Blauwendraat C, García-Ruiz S, Pease D, Mottier L, Carrella A, Beck-Schneider D, Magalhães AD, Aemisegger C, Theocharides APA, Fan Z, Marks JD, Hopp SC, Abramov AY, Lewis PA, Ryten M, Hardy J, Hyman BT, Aguzzi A. Kara E, et al. Among authors: heinzer d. Cell Rep. 2021 Jun 8;35(10):109189. doi: 10.1016/j.celrep.2021.109189. Cell Rep. 2021. PMID: 34107263 Free PMC article.
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. Meisl G, et al. Among authors: heinzer d. Nat Struct Mol Biol. 2021 Apr;28(4):365-372. doi: 10.1038/s41594-021-00565-x. Epub 2021 Mar 25. Nat Struct Mol Biol. 2021. PMID: 33767451 Free PMC article.
13 results