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Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Kschonsak YT, Gao X, Miller SE, Hwang S, Marei H, Wu P, Li Y, Ruiz K, Dorighi K, Holokai L, Perampalam P, Tsai WK, Kee YS, Agard NJ, Harris SF, Hannoush RN, de Sousa E Melo F. Kschonsak YT, et al. Among authors: hannoush rn. Cell Chem Biol. 2024 Jun 20;31(6):1176-1187.e10. doi: 10.1016/j.chembiol.2023.11.006. Epub 2023 Dec 5. Cell Chem Biol. 2024. PMID: 38056465
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H. Yun J, et al. Among authors: hannoush rn. Nat Commun. 2023 Jan 11;14(1):156. doi: 10.1038/s41467-022-35487-9. Nat Commun. 2023. PMID: 36631445 Free PMC article.
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling.
Hansen S, Zhang Y, Hwang S, Nabhan A, Li W, Fuhrmann J, Kschonsak Y, Zhou L, Nile AH, Gao X, Piskol R, de Sousa E Melo F, de Sauvage FJ, Hannoush RN. Hansen S, et al. Among authors: hannoush rn. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2207327119. doi: 10.1073/pnas.2207327119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343233 Free PMC article.
69 results