Williams JH - Search Results

1

Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors.

Piscitelli J, Reddy MB, Wollenberg L, Del Frari L, Gong J, Matschke K, Williams JH. Piscitelli J, et al. Among authors: williams jh. Cancer Chemother Pharmacol. 2024 Sep;94(3):337-347. doi: 10.1007/s00280-024-04676-2. Epub 2024 Jun 15. Cancer Chemother Pharmacol. 2024. PMID: 38878209 Free PMC article. Clinical Trial.

2

Clinical Evaluation of the Effect of Encorafenib on Bupropion, Rosuvastatin, and Coproporphyrin I and Considerations for Statin Coadministration.

Piscitelli J, Reddy MB, Wollenberg L, Del Frari L, Gong J, Wood L, Zhang Y, Matschke K, Williams JH. Piscitelli J, et al. Among authors: williams jh. Clin Pharmacokinet. 2024 Apr;63(4):483-496. doi: 10.1007/s40262-024-01352-9. Epub 2024 Feb 29. Clin Pharmacokinet. 2024. PMID: 38424308 Free PMC article. Clinical Trial.

3

A phase I, single-center, open-label study to investigate the absorption, distribution, metabolism and excretion of encorafenib following a single oral dose of 100 mg [¹⁴ C] encorafenib in healthy male subjects.

Wollenberg L, Hahn E, Williams J, Litwiler K. Wollenberg L, et al. Pharmacol Res Perspect. 2023 Oct;11(5):e01140. doi: 10.1002/prp2.1140. Pharmacol Res Perspect. 2023. PMID: 37775918 Free PMC article.

4

Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients.

Williams JH, Jayaraman B, Swoboda KJ, Barrett JS. Williams JH, et al. J Clin Pharmacol. 2012 Nov;52(11):1676-88. doi: 10.1177/0091270011428138. Epub 2011 Dec 13. J Clin Pharmacol. 2012. PMID: 22167565 Free PMC article. Clinical Trial.

5

A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development.

Udata C, Garzone PD, Gumbiner B, Joh T, Liang H, Liao KH, Williams JH, Meng X. Udata C, et al. Among authors: williams jh. J Clin Pharmacol. 2017 Jul;57(7):855-864. doi: 10.1002/jcph.867. Epub 2017 Feb 9. J Clin Pharmacol. 2017. PMID: 28181260

6

Comparative assessment of clinical response in patients with rheumatoid arthritis between PF-05280586, a proposed rituximab biosimilar, and rituximab.

Williams JH, Hutmacher MM, Zierhut ML, Becker JC, Gumbiner B, Spencer-Green G, Melia LA, Liao KH, Suster M, Yin D, Li R, Meng X. Williams JH, et al. Br J Clin Pharmacol. 2016 Dec;82(6):1568-1579. doi: 10.1111/bcp.13094. Epub 2016 Sep 22. Br J Clin Pharmacol. 2016. PMID: 27530379 Free PMC article. Clinical Trial.

7

Joint Disposition Properties and Comprehensive Pharmacokinetic Characterization of Antibody-Drug Conjugates.

Liao KH, Williams JH, Palani S, Yin D, Meng X. Liao KH, et al. Among authors: williams jh. AAPS J. 2022 Jun 10;24(4):73. doi: 10.1208/s12248-022-00717-x. AAPS J. 2022. PMID: 35688991

8

Implications of Immunogenicity Testing for Therapeutic Monoclonal Antibodies: A Quantitative Pharmacology Framework.

Williams JH, Liao KH, Yin D, Meng X. Williams JH, et al. AAPS J. 2024 Mar 7;26(2):31. doi: 10.1208/s12248-024-00901-1. AAPS J. 2024. PMID: 38453809

9

A phase 1 study of PF-06840003, an oral indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor in patients with recurrent malignant glioma.

Reardon DA, Desjardins A, Rixe O, Cloughesy T, Alekar S, Williams JH, Li R, Taylor CT, Lassman AB. Reardon DA, et al. Among authors: williams jh. Invest New Drugs. 2020 Dec;38(6):1784-1795. doi: 10.1007/s10637-020-00950-1. Epub 2020 May 20. Invest New Drugs. 2020. PMID: 32436060 Clinical Trial.

10

Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes.

Williams JH, Udata C, Ganguly BJ, Bucktrout SL, Joh T, Shannon M, Wong GY, Levisetti M, Garzone PD, Meng X. Williams JH, et al. AAPS J. 2020 Jan 3;22(2):23. doi: 10.1208/s12248-019-0401-3. AAPS J. 2020. PMID: 31900603 Free PMC article. Clinical Trial.

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