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Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy.
Pandya P, Vendetti FP, El-Ghoubaira J, Pathak S, Deppas JJ, Jones R, Columbus AV, Zhang Y, Ivanov D, Huang Z, MacDonald KM, Harding SM, Buj R, Aird KM, Beumer JH, Sobol RW, Bakkenist CJ. Pandya P, et al. Among authors: harding sm. bioRxiv [Preprint]. 2024 Apr 5:2024.04.04.588079. doi: 10.1101/2024.04.04.588079. bioRxiv. 2024. PMID: 38883769 Free PMC article. Preprint.
[No title available]
[No authors listed] [No authors listed] PMID: 38579672
The proteomic landscape of genotoxic stress-induced micronuclei.
MacDonald KM, Khan S, Lin B, Hurren R, Schimmer AD, Kislinger T, Harding SM. MacDonald KM, et al. Among authors: harding sm. Mol Cell. 2024 Apr 4;84(7):1377-1391.e6. doi: 10.1016/j.molcel.2024.02.001. Epub 2024 Feb 28. Mol Cell. 2024. PMID: 38423013 Free article.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O'Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD. Thomas GE, et al. Among authors: harding sm. Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9. Epub 2022 Jun 6. Nat Cell Biol. 2022. PMID: 35668135 Free PMC article.
163 results