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Recombineering and MAGE.
Wannier TM, Ciaccia PN, Ellington AD, Filsinger GT, Isaacs FJ, Javanmardi K, Jones MA, Kunjapur AM, Nyerges A, Pal C, Schubert MG, Church GM. Wannier TM, et al. Among authors: isaacs fj. Nat Rev Methods Primers. 2021;1:7. doi: 10.1038/s43586-020-00006-x. Epub 2021 Jan 14. Nat Rev Methods Primers. 2021. PMID: 35540496 Free PMC article.
Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations.
Zhang CH, Stone EA, Deshmukh M, Ippolito JA, Ghahremanpour MM, Tirado-Rives J, Spasov KA, Zhang S, Takeo Y, Kudalkar SN, Liang Z, Isaacs F, Lindenbach B, Miller SJ, Anderson KS, Jorgensen WL. Zhang CH, et al. ACS Cent Sci. 2021 Mar 24;7(3):467-475. doi: 10.1021/acscentsci.1c00039. Epub 2021 Feb 22. ACS Cent Sci. 2021. PMID: 33786375 Free PMC article.
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Zhang CH, Spasov KA, Reilly RA, Hollander K, Stone EA, Ippolito JA, Liosi ME, Deshmukh MG, Tirado-Rives J, Zhang S, Liang Z, Miller SJ, Isaacs F, Lindenbach BD, Anderson KS, Jorgensen WL. Zhang CH, et al. ACS Med Chem Lett. 2021 Jul 14;12(8):1325-1332. doi: 10.1021/acsmedchemlett.1c00326. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34408808 Free PMC article.
Recoded organisms engineered to depend on synthetic amino acids.
Rovner AJ, Haimovich AD, Katz SR, Li Z, Grome MW, Gassaway BM, Amiram M, Patel JR, Gallagher RR, Rinehart J, Isaacs FJ. Rovner AJ, et al. Among authors: isaacs fj. Nature. 2015 Feb 5;518(7537):89-93. doi: 10.1038/nature14095. Epub 2015 Jan 21. Nature. 2015. PMID: 25607356 Free PMC article.
70 results