Lou J - Search Results

1

Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.

Lou J, Zhou Q, Lyu X, Cen X, Liu C, Yan Z, Li Y, Tang H, Liu Q, Ding J, Lu Y, Huang H, Xie H, Zhao Y. Lou J, et al. J Med Chem. 2024 Jul 11;67(13):10795-10830. doi: 10.1021/acs.jmedchem.4c00291. Epub 2024 Jun 24. J Med Chem. 2024. PMID: 38913996

2

Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions.

Zhang S, Lou J, Li Y, Zhou F, Yan Z, Lyu X, Zhao Y. Zhang S, et al. Among authors: lou j. J Med Chem. 2021 Aug 12;64(15):10621-10640. doi: 10.1021/acs.jmedchem.1c00940. Epub 2021 Jul 21. J Med Chem. 2021. PMID: 34286973 Review.

3

Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells.

Feng X, Yan Z, Zhou F, Lou J, Lyu X, Ren X, Zeng Z, Liu C, Zhang S, Zhu D, Huang H, Yang J, Zhao Y. Feng X, et al. Among authors: lou j. Eur J Med Chem. 2022 Jun 5;236:114327. doi: 10.1016/j.ejmech.2022.114327. Epub 2022 Mar 29. Eur J Med Chem. 2022. PMID: 35385805

4

Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.

Zhang S, Yan Z, Li Y, Gong Y, Lyu X, Lou J, Zhang D, Meng X, Zhao Y. Zhang S, et al. Among authors: lou j. J Med Chem. 2022 Apr 28;65(8):6207-6230. doi: 10.1021/acs.jmedchem.2c00095. Epub 2022 Apr 14. J Med Chem. 2022. PMID: 35420431

5

A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities.

Lou J, Lu Y, Cheng J, Zhou F, Yan Z, Zhang D, Meng X, Zhao Y. Lou J, et al. Eur J Med Chem. 2022 Dec 5;243:114684. doi: 10.1016/j.ejmech.2022.114684. Epub 2022 Aug 30. Eur J Med Chem. 2022. PMID: 36063664 Review.

6

Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.

Yan Z, Lyu X, Lin D, Wu G, Gong Y, Ren X, Xiao J, Lou J, Huang H, Chen Y, Zhao Y. Yan Z, et al. Among authors: lou j. Eur J Med Chem. 2023 Jun 5;254:115381. doi: 10.1016/j.ejmech.2023.115381. Epub 2023 Apr 14. Eur J Med Chem. 2023. PMID: 37084596

7

Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo.

Lu Y, Yan Z, Sun J, Wang C, Xu L, Lyu X, Wang X, Lou J, Huang H, Meng L, Zhao Y. Lu Y, et al. Among authors: lou j. J Med Chem. 2025 Jan 13. doi: 10.1021/acs.jmedchem.4c02884. Online ahead of print. J Med Chem. 2025. PMID: 39804031

8

Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies.

Jian-Song, Gao QL, Wu BW, Li D, Shi L, Zhu T, Lou JF, Jin CY, Zhang YB, Zhang SY, Liu HM. Jian-Song, et al. Eur J Med Chem. 2019 Dec 1;183:111731. doi: 10.1016/j.ejmech.2019.111731. Epub 2019 Sep 25. Eur J Med Chem. 2019. PMID: 31577977

9

The Association Between Aspartate Transaminase to Alanine Transaminase Ratio and Perioperative Ischemic Stroke in Patients With Diabetes: A Retrospective Cohort Study.

Liu S, Wang B, Ma L, Yang H, Liu M, Song Y, Zhou Z, Lou J, Zhou D, Cao J, Liu Y, Mi W, Ma Y. Liu S, et al. Among authors: lou j. CNS Neurosci Ther. 2025 Jan;31(1):e70223. doi: 10.1111/cns.70223. CNS Neurosci Ther. 2025. PMID: 39838692

10

Hypoxia Promotes Malignant Progression of Colorectal Cancer by Inducing POSTN⁺ Cancer-Associated Fibroblast Formation.

Qin J, Hu S, Chen Y, Xu M, Xiao Q, Lou J, Ding M, Sun H, Xu T, Pan Y, Wang S. Qin J, et al. Among authors: lou j. Mol Carcinog. 2025 Jan 21. doi: 10.1002/mc.23882. Online ahead of print. Mol Carcinog. 2025. PMID: 39835715

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