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127 results

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Page 1
(S)-ML-SA1 Activates Autophagy via TRPML1-TFEB Pathway.
Cunha MR, Do Amaral BS, Takarada JE, Valderrama GV, Batista ANL, Batista JM Jr, Cass QB, Couñago RM, Massirer KB. Cunha MR, et al. Chembiochem. 2024 Jun 25:e202400506. doi: 10.1002/cbic.202400506. Online ahead of print. Chembiochem. 2024. PMID: 38923811
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Segretti ND, Takarada JE, Ferreira MA Jr, da Silva Santiago A, Teodoro BVM, Damião MCFCB, Godoi PH, Cunha MR, Fala AM, Ramos PZ, Ishikawa EE, Mascarello A, Serafim RAM, Azevedo H, Guimarães CRW, Couñago RM. Segretti ND, et al. Among authors: cunha mr. Bioorg Med Chem Lett. 2022 Jul 15;68:128764. doi: 10.1016/j.bmcl.2022.128764. Epub 2022 May 2. Bioorg Med Chem Lett. 2022. PMID: 35504513
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM. Takarada JE, et al. Among authors: cunha mr. Bioorg Med Chem. 2024 Jan 15;98:117561. doi: 10.1016/j.bmc.2023.117561. Epub 2023 Dec 20. Bioorg Med Chem. 2024. PMID: 38157838 Free article.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
de Souza Gama FH, Dutra LA, Hawgood M, Dos Reis CV, Serafim RAM, Ferreira MA Jr, Teodoro BVM, Takarada JE, Santiago AS, Balourdas DI, Nilsson AS, Urien B, Almeida VM, Gileadi C, Ramos PZ, Salmazo A, Vasconcelos SNS, Cunha MR, Mueller S, Knapp S, Massirer KB, Elkins JM, Gileadi O, Mascarello A, Lemmens BBLG, Guimarães CRW, Azevedo H, Couñago RM. de Souza Gama FH, et al. Among authors: cunha mr. J Med Chem. 2024 Jun 13;67(11):8609-8629. doi: 10.1021/acs.jmedchem.3c02250. Epub 2024 May 23. J Med Chem. 2024. PMID: 38780468
Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens.
Andrade Meirelles M, Almeida VM, Sullivan JR, de Toledo I, Dos Reis CV, Cunha MR, Zigweid R, Shim A, Sankaran B, Woodward EL, Seibold S, Liu L, Mian MR, Battaile KP, Riley J, Duncan C, Simeons FRC, Ferguson L, Joji H, Read KD, Lovell S, Staker BL, Behr MA, Pilli RA, Couñago RM. Andrade Meirelles M, et al. Among authors: cunha mr. J Med Chem. 2024 Oct 28. doi: 10.1021/acs.jmedchem.4c01594. Online ahead of print. J Med Chem. 2024. PMID: 39468773
Peppers: A "Hot" Natural Source for Antitumor Compounds.
Cunha MR, Tavares MT, Fernandes TB, Parise-Filho R. Cunha MR, et al. Molecules. 2021 Mar 10;26(6):1521. doi: 10.3390/molecules26061521. Molecules. 2021. PMID: 33802144 Free PMC article. Review.
Transcriptional regulators of fetal hemoglobin.
Santos GPD, Rabi LT, Bezerra AA, da Cunha MR, Iatecola A, Fernandes VAR. Santos GPD, et al. Among authors: da cunha mr. Hematol Transfus Cell Ther. 2024 Aug 17:S2531-1379(24)00296-7. doi: 10.1016/j.htct.2024.06.001. Online ahead of print. Hematol Transfus Cell Ther. 2024. PMID: 39237431 Free article. Review.
127 results