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Page 1
Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles.
da Silva Oliveira DD, Sousa Silva NB, Jacques Dit Lapierre TJW, Lemes de Souza S, Ferreira Brito NP, Cassiano Martinho AC, Clemente Dias RF, Nascimento Farago D, Michelan-Duarte S, Consolin Chelucci R, de Moura Lodi Cruz MGF, de Melo Resende D, Andricopulo AD, Fonseca Murta SM, Ferreira LLG, Gomes Martins CH, de Oliveira Rezende Júnior C. da Silva Oliveira DD, et al. Among authors: michelan duarte s. Chem Biodivers. 2024 Sep 26:e202402100. doi: 10.1002/cbdv.202402100. Online ahead of print. Chem Biodivers. 2024. PMID: 39327235
Structure-Metabolism Relationships of Benzimidazole Derivatives with anti-Trypanosoma cruzi Activity for Chagas Disease.
Espinoza-Chávez RM, de Oliveira Rezende Júnior C, Laureano de Souza M, Consolin Chelucci R, Michelan-Duarte S, Krogh R, Gomes Ferreira LL, Valli M, Sena de Oliveira A, Andricopulo AD, Carlos Dias L. Espinoza-Chávez RM, et al. Among authors: michelan duarte s. ChemMedChem. 2024 Oct 16;19(20):e202400293. doi: 10.1002/cmdc.202400293. Epub 2024 Aug 27. ChemMedChem. 2024. PMID: 38924252
Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum.
Lapierre TJWJD, Farago DN, de Moura Lodi Cruz MGF, de Melo Resende D, de Oliveira ACR, Dos Santos BRM, de Oliveira Souza F, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Ferreira LLG, Pilau EJ, Murta SMF, de Oliveira Rezende Júnior C. Lapierre TJWJD, et al. Among authors: michelan duarte s. Chem Biol Drug Des. 2024 Apr;103(4):e14525. doi: 10.1111/cbdd.14525. Chem Biol Drug Des. 2024. PMID: 38627214
Structure-activity relationships of novel N-imidazoylpiperazines with potent anti-Trypanosoma cruzi activity.
Espinoza-Chávez RM, Oliveira Rezende Júnior C, de Souza ML, Pauli I, Valli M, Gomes Ferreira LL, Chelucci RC, Michelan-Duarte S, Krogh R, Romualdo da Silva FB, Cruz FC, de Oliveira AS, Andricopulo AD, Dias LC. Espinoza-Chávez RM, et al. Among authors: michelan duarte s. Future Med Chem. 2024 Feb;16(3):253-269. doi: 10.4155/fmc-2023-0185. Epub 2024 Jan 9. Future Med Chem. 2024. PMID: 38193294
Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease.
de Oliveira Rezende Júnior C, Martinez PDG, Ferreira RAA, Koovits PJ, Miranda Soares B, Ferreira LLG, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Matheeussen A, Van Pelt N, Caljon G, Maes L, Campbell S, Kratz JM, Mowbray CE, Dias LC. de Oliveira Rezende Júnior C, et al. Among authors: michelan duarte s. Eur J Med Chem. 2023 Jan 15;246:114925. doi: 10.1016/j.ejmech.2022.114925. Epub 2022 Nov 15. Eur J Med Chem. 2023. PMID: 36459758 Free article.
Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics.
Pauli I, Rezende CO Jr, Slafer BW, Dessoy MA, de Souza ML, Ferreira LLG, Adjanohun ALM, Ferreira RS, Magalhães LG, Krogh R, Michelan-Duarte S, Del Pintor RV, da Silva FBR, Cruz FC, Dias LC, Andricopulo AD. Pauli I, et al. Among authors: michelan duarte s. Front Pharmacol. 2022 Jan 5;12:774069. doi: 10.3389/fphar.2021.774069. eCollection 2021. Front Pharmacol. 2022. PMID: 35069198 Free PMC article.
Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure-activity relationships.
de Oliveira AS, S Mello LD, H Ogihara C, H Döring T, L Palomino-Salcedo D, Michelan-Duarte S, Lg Ferreira L, M Souza J, Dávila-Rodríguez MJ, Cruz Júnior JWD, R Dockal E, D Andricopulo A. de Oliveira AS, et al. Among authors: michelan duarte s. Future Med Chem. 2021 Dec;13(24):2167-2183. doi: 10.4155/fmc-2021-0194. Epub 2021 Oct 28. Future Med Chem. 2021. PMID: 34708659
2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling.
Ferreira RAA, Junior COR, Martinez PDG, Koovits PJ, Soares BM, Ferreira LLG, Michelan-Duarte S, Chelucci RC, Andricopulo AD, Galuppo MK, Uliana SRB, Matheeussen A, Caljon G, Maes L, Campbell S, Kratz JM, Mowbray CE, Dias LC. Ferreira RAA, et al. Among authors: michelan duarte s. PLoS Negl Trop Dis. 2021 Feb 22;15(2):e0009196. doi: 10.1371/journal.pntd.0009196. eCollection 2021 Feb. PLoS Negl Trop Dis. 2021. PMID: 33617566 Free PMC article.
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