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1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.
Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A. Fernández F, et al. Among authors: nicolotti o. Bioorg Med Chem. 2009 May 15;17(10):3618-29. doi: 10.1016/j.bmc.2009.03.062. Epub 2009 Apr 5. Bioorg Med Chem. 2009. PMID: 19398343
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.
Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437843
Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.
Pisani L, Farina R, Soto-Otero R, Denora N, Mangiatordi GF, Nicolotti O, Mendez-Alvarez E, Altomare CD, Catto M, Carotti A. Pisani L, et al. Among authors: nicolotti o. Molecules. 2016 Mar 17;21(3):362. doi: 10.3390/molecules21030362. Molecules. 2016. PMID: 26999091 Free PMC article.
Ion Channels in Drug Discovery and Safety Pharmacology.
Imbrici P, Nicolotti O, Leonetti F, Conte D, Liantonio A. Imbrici P, et al. Among authors: nicolotti o. Methods Mol Biol. 2018;1800:313-326. doi: 10.1007/978-1-4939-7899-1_15. Methods Mol Biol. 2018. PMID: 29934900 Review.
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules.
Pisani L, Catto M, Muncipinto G, Nicolotti O, Carrieri A, Rullo M, Stefanachi A, Leonetti F, Altomare C. Pisani L, et al. Among authors: nicolotti o. Front Chem. 2022 Oct 10;10:1002547. doi: 10.3389/fchem.2022.1002547. eCollection 2022. Front Chem. 2022. PMID: 36300022 Free PMC article. Review.
170 results