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Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase.
Palmer N, Agnew C, Benn C, Buffham WJ, Castro JN, Chessari G, Clark M, Cons BD, Coyle JE, Dawson LA, Hamlett CCF, Hodson C, Holding F, Johnson CN, Liebeschuetz JW, Mahajan P, McCarthy JM, Murray CW, O'Reilly M, Peakman T, Price A, Rapti M, Reeks J, Schöpf P, St-Denis JD, Valenzano C, Wallis NG, Walser R, Weir H, Wilsher NE, Woodhead A, Bento CF, Tisi D. Palmer N, et al. Among authors: price a. J Med Chem. 2024 Jul 11;67(13):11168-11181. doi: 10.1021/acs.jmedchem.4c00702. Epub 2024 Jun 27. J Med Chem. 2024. PMID: 38932616
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
Day JEH, Berdini V, Castro J, Chessari G, Davies TG, Day PJ, St Denis JD, Fujiwara H, Fukaya S, Hamlett CCF, Hearn K, Hiscock SD, Holvey RS, Ito S, Kandola N, Kodama Y, Liebeschuetz JW, Martins V, Matsuo K, Mortenson PN, Muench S, Nakatsuru Y, Ochiiwa H, Palmer N, Peakman T, Price A, Reader M, Rees DC, Rich SJ, Shah A, Shibata Y, Smyth T, Twigg DG, Wallis NG, Williams G, Wilsher NE, Woodhead A, Shimamura T, Johnson CN. Day JEH, et al. Among authors: price a. J Med Chem. 2024 Mar 28;67(6):4655-4675. doi: 10.1021/acs.jmedchem.3c02118. Epub 2024 Mar 10. J Med Chem. 2024. PMID: 38462716
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study.
Gharibzadeh S, Routen A, Razieh C, Zaccardi F, Lawson C, Gillies C, Heller S, Davies M, Atkins H, Bain SC, Lone NL, Poinasamy K, Peto T, Robertson E, Young B, Johnston D, Quint J, Valabhji J, Ismail K, Marks M, Horsley A, Docherty A, Harrison E, Chalmers J, Ho LP, Raman B, Brightling C, Elneima O, Evans R, Greening N, Harris VC, Houchen-Wolloff L, Sereno M, Shikotra A, Singapuri A, Wain L, Langenberg C, Dennis J, Petrie J, Sattar N, Leavy O, Richardson M, Saunders RM, McArdle A, McASuley H, Yates T, Khunti K; PHOSP-COVID Study Collaborative Group. Gharibzadeh S, et al. EClinicalMedicine. 2024 Dec 27;79:103005. doi: 10.1016/j.eclinm.2024.103005. eCollection 2025 Jan. EClinicalMedicine. 2024. PMID: 39834716 Free PMC article.
Characterizing substructure via mixture modeling in large-scale genetic summary statistics.
Stoneman HR, Price AM, Trout NS, Lamont R, Tifour S, Pozdeyev N; Colorado Center for Personalized Medicine; Crooks K, Lin M, Rafaels N, Gignoux CR, Marker KM, Hendricks AE. Stoneman HR, et al. Among authors: price am. Am J Hum Genet. 2025 Jan 11:S0002-9297(24)00449-X. doi: 10.1016/j.ajhg.2024.12.007. Online ahead of print. Am J Hum Genet. 2025. PMID: 39824191 Free article.
2,896 results