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The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.
Ribeiro FC, Cozachenco D, Argyrousi EK, Staniszewski A, Wiebe S, Calixtro JD, Soares-Neto R, Al-Chami A, Sayegh FE, Bermudez S, Arsenault E, Cossenza M, Lacaille JC, Nader K, Sun H, De Felice FG, Lourenco MV, Arancio O, Aguilar-Valles A, Sonenberg N, Ferreira ST. Ribeiro FC, et al. Among authors: calixtro jd. Alzheimers Dement. 2024 Aug;20(8):5398-5410. doi: 10.1002/alz.14034. Epub 2024 Jun 27. Alzheimers Dement. 2024. PMID: 38934107 Free PMC article.