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Page 1
Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1.
Rijpkema KJ, Schuller M, van der Veer MS, Rieken S, Chang DLR, Balić P, Todorov A, Minnee H, Wijngaarden S, Matos IA, Hoch NC, Codée JDC, Ahel I, Filippov DV. Rijpkema KJ, et al. Among authors: hoch nc. Org Lett. 2024 Jul 12;26(27):5700-5704. doi: 10.1021/acs.orglett.4c01792. Epub 2024 Jun 27. Org Lett. 2024. PMID: 38935522 Free PMC article.
Asymmetric synthesis of umuravumbolide.
Reddy MV, Rearick JP, Hoch N, Ramachandran PV. Reddy MV, et al. Org Lett. 2001 Jan 11;3(1):19-20. doi: 10.1021/ol006583z. Org Lett. 2001. PMID: 11429860
The PARP inhibitor rucaparib blocks SARS-CoV-2 virus binding to cells and the immune reaction in models of COVID-19.
Papp H, Tóth E, Bóvári-Biri J, Bánfai K, Juhász P, Mahdi M, Russo LC, Bajusz D, Sipos A, Petri L, Szalai TV, Kemény Á, Madai M, Kuczmog A, Batta G, Mózner O, Vaskó D, Hirsch E, Bohus P, Méhes G, Tőzsér J, Curtin NJ, Helyes Z, Tóth A, Hoch NC, Jakab F, Keserű GM, Pongrácz JE, Bai P. Papp H, et al. Among authors: hoch nc. Br J Pharmacol. 2024 Dec;181(23):4782-4803. doi: 10.1111/bph.17305. Epub 2024 Aug 27. Br J Pharmacol. 2024. PMID: 39191429
Rothmund-Thomson syndrome, a disorder far from solved.
Martins DJ, Di Lazzaro Filho R, Bertola DR, Hoch NC. Martins DJ, et al. Among authors: hoch nc. Front Aging. 2023 Nov 10;4:1296409. doi: 10.3389/fragi.2023.1296409. eCollection 2023. Front Aging. 2023. PMID: 38021400 Free PMC article. Review.
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
Serrano-Benitez A, Wells SE, Drummond-Clarke L, Russo LC, Thomas JC, Leal GA, Farrow M, Edgerton JM, Balasubramanian S, Yang M, Frezza C, Gautam A, Brazina J, Burdova K, Hoch NC, Jackson SP, Caldecott KW. Serrano-Benitez A, et al. Among authors: hoch nc. EMBO J. 2023 Sep 18;42(18):e113190. doi: 10.15252/embj.2022113190. Epub 2023 Jul 26. EMBO J. 2023. PMID: 37492888 Free PMC article.
Tissue Specificity of DNA Damage and Repair.
Hoch NC. Hoch NC. Physiology (Bethesda). 2023 Sep 1;38(5):0. doi: 10.1152/physiol.00006.2023. Epub 2023 May 30. Physiology (Bethesda). 2023. PMID: 37253212 Free article. Review.
29 results