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The SARS-CoV-2 main protease as drug target.
Ullrich S, Nitsche C. Ullrich S, et al. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127377. doi: 10.1016/j.bmcl.2020.127377. Epub 2020 Jul 2. Bioorg Med Chem Lett. 2020. PMID: 32738988 Free PMC article. Review.
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.
Ullrich S, Sasi VM, Mahawaththa MC, Ekanayake KB, Morewood R, George J, Shuttleworth L, Zhang X, Whitefield C, Otting G, Jackson C, Nitsche C. Ullrich S, et al. Bioorg Med Chem Lett. 2021 Oct 15;50:128333. doi: 10.1016/j.bmcl.2021.128333. Epub 2021 Aug 19. Bioorg Med Chem Lett. 2021. PMID: 34418570 Free PMC article.
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.
Johansen-Leete J, Ullrich S, Fry SE, Frkic R, Bedding MJ, Aggarwal A, Ashhurst AS, Ekanayake KB, Mahawaththa MC, Sasi VM, Luedtke S, Ford DJ, O'Donoghue AJ, Passioura T, Larance M, Otting G, Turville S, Jackson CJ, Nitsche C, Payne RJ. Johansen-Leete J, et al. Among authors: ullrich s. Chem Sci. 2022 Feb 28;13(13):3826-3836. doi: 10.1039/d1sc06750h. eCollection 2022 Mar 30. Chem Sci. 2022. PMID: 35432913 Free PMC article.
Biocompatible and Selective Generation of Bicyclic Peptides.
Ullrich S, George J, Coram AE, Morewood R, Nitsche C. Ullrich S, et al. Angew Chem Int Ed Engl. 2022 Oct 24;61(43):e202208400. doi: 10.1002/anie.202208400. Epub 2022 Aug 22. Angew Chem Int Ed Engl. 2022. PMID: 35852030 Free PMC article.
Probing Ligand Binding Sites on Large Proteins by Nuclear Magnetic Resonance Spectroscopy of Genetically Encoded Non-Canonical Amino Acids.
Ekanayake KB, Mahawaththa MC, Qianzhu H, Abdelkader EH, George J, Ullrich S, Murphy RB, Fry SE, Johansen-Leete J, Payne RJ, Nitsche C, Huber T, Otting G. Ekanayake KB, et al. Among authors: ullrich s. J Med Chem. 2023 Apr 13;66(7):5289-5304. doi: 10.1021/acs.jmedchem.3c00222. Epub 2023 Mar 15. J Med Chem. 2023. PMID: 36920850
649 results