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Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.
Zumerle S, Sarill M, Saponaro M, Colucci M, Contu L, Lazzarini E, Sartori R, Pezzini C, Rinaldi A, Scanu A, Sgrignani J, Locatelli P, Sabbadin M, Valdata A, Brina D, Giacomini I, Rizzo B, Pierantoni A, Sharifi S, Bressan S, Altomare C, Goshovska Y, Giraudo C, Luisetto R, Iaccarino L, Torcasio C, Mosole S, Pasquini E, Rinaldi A, Pellegrini L, Peron G, Fassan M, Masiero S, Giori AM, Dall'Acqua S, Auwerx J, Cippà P, Cavalli A, Bolis M, Sandri M, Barile L, Montopoli M, Alimonti A. Zumerle S, et al. Among authors: auwerx j. Nat Aging. 2024 Sep;4(9):1231-1248. doi: 10.1038/s43587-024-00663-7. Epub 2024 Jul 1. Nat Aging. 2024. PMID: 38951692 Free PMC article.
Mitophagy in human health, ageing and disease.
Picca A, Faitg J, Auwerx J, Ferrucci L, D'Amico D. Picca A, et al. Among authors: auwerx j. Nat Metab. 2023 Dec;5(12):2047-2061. doi: 10.1038/s42255-023-00930-8. Epub 2023 Nov 30. Nat Metab. 2023. PMID: 38036770 Review.
Cyclo(His-Pro): A further step in the management of steatohepatitis.
De Masi A, Li X, Lee D, Jeon J, Wang Q, Baek S, Park O, Mottis A, Strotjohann K, Rapin A, Jung HY, Auwerx J. De Masi A, et al. Among authors: auwerx j. JHEP Rep. 2023 Jun 10;5(9):100815. doi: 10.1016/j.jhepr.2023.100815. eCollection 2023 Sep. JHEP Rep. 2023. PMID: 37600955 Free PMC article.
Systems genetics of metabolic health in the BXD mouse genetic reference population.
Li X, Morel JD, Sulc J, De Masi A, Lalou A, Benegiamo G, Poisson J, Liu Y, Von Alvensleben GVG, Gao AW, Bou Sleiman M, Auwerx J. Li X, et al. Among authors: auwerx j. Cell Syst. 2024 Jun 19;15(6):497-509.e3. doi: 10.1016/j.cels.2024.05.006. Epub 2024 Jun 11. Cell Syst. 2024. PMID: 38866010 Free article.
ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH.
Liu YJ, Kimura M, Li X, Sulc J, Wang Q, Rodríguez-López S, Scantlebery AML, Strotjohann K, Gallart-Ayala H, Vijayakumar A, Myers RP, Ivanisevic J, Houtkooper RH, Subramanian GM, Takebe T, Auwerx J. Liu YJ, et al. Among authors: auwerx j. J Hepatol. 2024 Aug 22:S0168-8278(24)02484-X. doi: 10.1016/j.jhep.2024.08.009. Online ahead of print. J Hepatol. 2024. PMID: 39181211 Free article.
High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.
Gao AW, El Alam G, Zhu Y, Li W, Sulc J, Li X, Katsyuba E, Li TY, Overmyer KA, Lalou A, Mouchiroud L, Sleiman MB, Cornaglia M, Morel JD, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. Among authors: auwerx j. Cell Rep. 2024 Oct 22;43(10):114836. doi: 10.1016/j.celrep.2024.114836. Epub 2024 Oct 4. Cell Rep. 2024. PMID: 39368088 Free article.
635 results