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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Among authors: cheresh d. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer.
Testa A, Quaglia F, Naranjo NM, Verrillo CE, Shields CD, Lin S, Pickles MW, Hamza DF, Von Schalscha T, Cheresh DA, Leiby B, Liu Q, Ding J, Kelly WK, Hooper DC, Corey E, Plow EF, Altieri DC, Languino LR. Testa A, et al. Among authors: cheresh da. Matrix Biol. 2023 Dec;124:49-62. doi: 10.1016/j.matbio.2023.11.003. Epub 2023 Nov 11. Matrix Biol. 2023. PMID: 37956856 Free PMC article.
Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
Wu C, Rakhshandehroo T, Wettersten HI, Campos A, von Schalscha T, Jain S, Yu Z, Tan J, Mose E, Childers BG, Lowy AM, Weis SM, Cheresh DA. Wu C, et al. Among authors: cheresh da. Nat Cell Biol. 2023 Feb;25(2):309-322. doi: 10.1038/s41556-022-01055-y. Epub 2023 Jan 16. Nat Cell Biol. 2023. PMID: 36646789 Free PMC article.
Metastasis is a highly stressful process.
Campos AD, Weis SM, Cheresh DA. Campos AD, et al. Among authors: cheresh da. Cancer Metastasis Rev. 2020 Dec;39(4):1021-1022. doi: 10.1007/s10555-020-09938-y. Epub 2020 Nov 6. Cancer Metastasis Rev. 2020. PMID: 33159274 Free PMC article.
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. Zhu Z, et al. Among authors: cheresh da. Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10. doi: 10.1016/j.stem.2019.11.016. Epub 2020 Jan 16. Cell Stem Cell. 2020. PMID: 31956038 Free PMC article.
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression.
Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. Wettersten HI, et al. Among authors: cheresh da. Cancer Res. 2019 Oct 1;79(19):5048-5059. doi: 10.1158/0008-5472.CAN-19-1246. Epub 2019 Aug 15. Cancer Res. 2019. PMID: 31416839 Free PMC article.
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.
Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, Ghajar CM. Carlson P, et al. Among authors: cheresh da. Nat Cell Biol. 2019 Feb;21(2):238-250. doi: 10.1038/s41556-018-0267-0. Epub 2019 Jan 21. Nat Cell Biol. 2019. PMID: 30664790 Free PMC article.
254 results