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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Among authors: coussens lm. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.
Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. Gunderson AJ, et al. Among authors: coussens lm. Cancer Discov. 2016 Mar;6(3):270-85. doi: 10.1158/2159-8290.CD-15-0827. Epub 2015 Dec 29. Cancer Discov. 2016. PMID: 26715645 Free PMC article.
Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study.
Taylor MH, Betts CB, Maloney L, Nadler E, Algazi A, Guarino MJ, Nemunaitis J, Jimeno A, Patel P, Munugalavadla V, Tao L, Adkins D, Goldschmidt JH, Cohen EEW, Coussens LM. Taylor MH, et al. Among authors: coussens lm. Clin Cancer Res. 2022 Mar 1;28(5):903-914. doi: 10.1158/1078-0432.CCR-21-2547. Clin Cancer Res. 2022. PMID: 34862248 Free PMC article. Clinical Trial.
Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate BJ, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. Among authors: coussens lm. Cancer Immunol Res. 2024 May 2;12(5):544-558. doi: 10.1158/2326-6066.CIR-23-0873. Cancer Immunol Res. 2024. PMID: 38381401 Free PMC article.
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.
Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen CC, Cheresh DA, Anand S. Wilson R, et al. Among authors: coussens lm. Nat Commun. 2016 Nov 25;7:13597. doi: 10.1038/ncomms13597. Nat Commun. 2016. PMID: 27886180 Free PMC article.
Beyond Programmed Death-Ligand 1: B7-H6 Emerges as a Potential Immunotherapy Target in SCLC.
Thomas PL, Groves SM, Zhang YK, Li J, Gonzalez-Ericsson P, Sivagnanam S, Betts CB, Chen HC, Liu Q, Lowe C, Chen H, Boyd KL, Kopparapu PR, Yan Y, Coussens LM, Quaranta V, Tyson DR, Iams W, Lovly CM. Thomas PL, et al. Among authors: coussens lm. J Thorac Oncol. 2021 Jul;16(7):1211-1223. doi: 10.1016/j.jtho.2021.03.011. Epub 2021 Apr 8. J Thorac Oncol. 2021. PMID: 33839362 Free PMC article.
Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma.
Link JM, Liudahl SM, Betts CB, Sivagnanam S, Leis KR, McDonnell M, Pelz CR, Johnson B, Hamman KJ, Keith D, Sampson JE, Morgan TK, Lopez CD, Coussens LM, Sears RC. Link JM, et al. Among authors: coussens lm. JCO Precis Oncol. 2021 Feb 5;5:PO.20.00287. doi: 10.1200/PO.20.00287. eCollection 2021. JCO Precis Oncol. 2021. PMID: 34036232 Free PMC article. No abstract available.
A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.
Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, Nagarajan S, Diaz L, Sandborg H, Bhattacharyya S, Xia Z, Coussens LM, Tontonoz P, Sherman MH. Abrego J, et al. Among authors: coussens lm. Cancer Discov. 2022 Oct 5;12(10):2414-2433. doi: 10.1158/2159-8290.CD-22-0661. Cancer Discov. 2022. PMID: 35894778 Free PMC article.
193 results