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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.
O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R Jr, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. O'Connell BC, et al. J Immunother Cancer. 2024 Aug 30;12(8):e009160. doi: 10.1136/jitc-2024-009160. J Immunother Cancer. 2024. PMID: 39214650 Free PMC article. Clinical Trial.
Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial.
Hong DS, Postow M, Chmielowski B, Sullivan R, Patnaik A, Cohen EEW, Shapiro G, Steuer C, Gutierrez M, Yeckes-Rodin H, Ilaria R, O'Connell B, Peng J, Peng G, Zizlsperger N, Tolcher A, Wolchok JD. Hong DS, et al. Clin Cancer Res. 2023 Jun 13;29(12):2210-2219. doi: 10.1158/1078-0432.CCR-22-3313. Clin Cancer Res. 2023. PMID: 37000164 Free PMC article. Clinical Trial.
Atlas-scale single-cell DNA methylation profiling with sciMETv3.
Nichols RV, Rylaarsdam LE, O'Connell BL, Shipony Z, Iremadze N, Acharya SN, Adey AC. Nichols RV, et al. Among authors: o connell bl. Cell Genom. 2024 Dec 17:100726. doi: 10.1016/j.xgen.2024.100726. Online ahead of print. Cell Genom. 2024. PMID: 39719707 Free article.
A 4-year outbreak of MRSA ST72-MRSA-IV spa type t1597 in a surgical high dependency unit in Ireland linked to repeated healthcare worker recolonisation.
Brady D, Brennan G, O'Connell B, Buckley R, Brennan M, Lenehan M, Jerry J, Nolke L, Javadpour SH, Hannan MM, Lynch B, Lynch M. Brady D, et al. Among authors: o connell b. Infect Prev Pract. 2024 Nov 15;7(1):100421. doi: 10.1016/j.infpip.2024.100421. eCollection 2025 Mar. Infect Prev Pract. 2024. PMID: 39687552 Free PMC article.
Successful control of an outbreak of Panton-Valentine leucocidin positive meticillin resistant Staphylococcus aureus in a National Burns Unit through early detection by whole genome sequencing.
Traynor R, Brennan GI, Hoban T, Dolan AM, Boyle B, O' Connell B, Shelley O, Teoh TK. Traynor R, et al. Among authors: o connell b. Infect Prev Pract. 2024 Sep 24;6(4):100400. doi: 10.1016/j.infpip.2024.100400. eCollection 2024 Dec. Infect Prev Pract. 2024. PMID: 39483423 Free PMC article.
Vitamin D, periodontitis and tooth loss in older Irish adults.
Winning L, Scarlett S, Crowe M, O'Sullivan M, Kenny RA, O'Connell B. Winning L, et al. Among authors: o connell b. Br J Nutr. 2024 Sep 18;132(4):1-9. doi: 10.1017/S000711452400148X. Online ahead of print. Br J Nutr. 2024. PMID: 39290089 Free PMC article.
Graduating European Dentist Curriculum Domain V: Research.
Field J, Dixon J, Vital S, Murphy D, O'Connell B, Davies J. Field J, et al. Among authors: o connell b. Eur J Dent Educ. 2024 Nov;28(4):1047-1051. doi: 10.1111/eje.13040. Epub 2024 Sep 14. Eur J Dent Educ. 2024. PMID: 39276377
639 results