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A "Prime and Expand" strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy.
Shrestha N, Dee MJ, Chaturvedi P, Leclerc GM, Mathyer M, Dufour C, Arthur L, Becker-Hapak M, Foster M, McClain E, Pena NV, Kage K, Zhu X, George V, Liu B, Egan J, Echeverri C, Wang M, You L, Kong L, Li L, Berrien-Elliott MM, Cooper ML, Fehniger TA, Rhode PR, Wong HC. Shrestha N, et al. Among authors: echeverri c. Cancer Immunol Immunother. 2024 Jul 3;73(9):179. doi: 10.1007/s00262-024-03765-8. Cancer Immunol Immunother. 2024. PMID: 38960949 Free PMC article.
Bifunctional TGF-β trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors.
Liu B, Zhu X, Kong L, Wang M, Spanoudis C, Chaturvedi P, George V, Jiao JA, You L, Egan JO, Echeverri C, Gallo VL, Xing J, Ravelo K, Prendes C, Antolinez J, Denissova J, Muniz GJ, Jeng EK, Rhode PR, Wong HC. Liu B, et al. Among authors: echeverri c. Mol Ther. 2021 Oct 6;29(10):2949-2962. doi: 10.1016/j.ymthe.2021.06.001. Epub 2021 Jun 4. Mol Ther. 2021. PMID: 34091051 Free PMC article.
A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy.
Becker-Hapak MK, Shrestha N, McClain E, Dee MJ, Chaturvedi P, Leclerc GM, Marsala LI, Foster M, Schappe T, Tran J, Desai S, Neal CC, Pence P, Wong P, Wagner JA, Russler-Germain DA, Zhu X, Spanoudis CM, Gallo VL, Echeverri CA, Ramirez LL, You L, Egan JO, Rhode PR, Jiao JA, Muniz GJ, Jeng EK, Prendes CA, Sullivan RP, Berrien-Elliott MM, Wong HC, Fehniger TA. Becker-Hapak MK, et al. Among authors: echeverri ca. Cancer Immunol Res. 2021 Sep;9(9):1071-1087. doi: 10.1158/2326-6066.CIR-20-1002. Epub 2021 Jul 9. Cancer Immunol Res. 2021. PMID: 34244297 Free PMC article.
Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.
Chaturvedi P, George V, Shrestha N, Wang M, Dee MJ, Zhu X, Liu B, Egan J, D'Eramo F, Spanoudis C, Gallo V, Echeverri C, You L, Kong L, Fang B, Jeng EK, Rhode PR, Wong HC. Chaturvedi P, et al. Among authors: echeverri c. Mol Ther. 2022 Mar 2;30(3):1171-1187. doi: 10.1016/j.ymthe.2022.01.025. Epub 2022 Jan 17. Mol Ther. 2022. PMID: 35051615 Free PMC article.
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Zhu X, Li Q, George V, Spanoudis C, Gilkes C, Shrestha N, Liu B, Kong L, You L, Echeverri C, Li L, Wang Z, Chaturvedi P, Muniz GJ, Egan JO, Rhode PR, Wong HC. Zhu X, et al. Among authors: echeverri c. Front Immunol. 2023 Jan 25;14:1114802. doi: 10.3389/fimmu.2023.1114802. eCollection 2023. Front Immunol. 2023. PMID: 36761778 Free PMC article.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Shrestha N, Chaturvedi P, Zhu X, Dee MJ, George V, Janney C, Egan JO, Liu B, Foster M, Marsala L, Wong P, Cubitt CC, Foltz JA, Tran J, Schappe T, Hsiao K, Leclerc GM, You L, Echeverri C, Spanoudis C, Carvalho A, Kanakaraj L, Gilkes C, Encalada N, Kong L, Wang M, Fang B, Wang Z, Jiao JA, Muniz GJ, Jeng EK, Valdivieso N, Li L, Deth R, Berrien-Elliott MM, Fehniger TA, Rhode PR, Wong HC. Shrestha N, et al. Among authors: echeverri c. Aging Cell. 2023 May;22(5):e13806. doi: 10.1111/acel.13806. Epub 2023 Mar 26. Aging Cell. 2023. PMID: 36967480 Free PMC article.
American society for metabolic and bariatric surgery: intra-operative care pathway for minimally invasive Roux-en-Y gastric bypass.
Lin H, Baker JW, Meister K, Lak KL, Martin Del Campo SE, Smith A, Needleman B, Nadzam G, Ying LD, Varban O, Reyes AM, Breckenbridge J, Tabone L, Gentles C, Echeverri C, Jones SB, Gould J, Vosburg W, Jones DB, Edwards M, Nimeri A, Kindel T, Petrick A. Lin H, et al. Among authors: echeverri c. Surg Obes Relat Dis. 2024 Oct;20(10):895-909. doi: 10.1016/j.soard.2024.06.002. Epub 2024 Jun 19. Surg Obes Relat Dis. 2024. PMID: 39097472 Free article.
73 results