Webb CT - Search Results

1

Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.

Giannangelo C, Challis MP, Siddiqui G, Edgar R, Malcolm TR, Webb CT, Drinkwater N, Vinh N, Macraild C, Counihan N, Duffy S, Wittlin S, Devine SM, Avery VM, De Koning-Ward T, Scammells P, McGowan S, Creek DJ. Giannangelo C, et al. Among authors: webb ct. Elife. 2024 Jul 8;13:RP92990. doi: 10.7554/eLife.92990. Elife. 2024. PMID: 38976500 Free PMC article.

2

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.

Malcolm TR, Swiderska KW, Hayes BK, Webb CT, Drag M, Drinkwater N, McGowan S. Malcolm TR, et al. Among authors: webb ct. Biochem J. 2021 Jul 16;478(13):2697-2713. doi: 10.1042/BCJ20210172. Biochem J. 2021. PMID: 34133730 Free PMC article.

3

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.

Edgar RCS, Siddiqui G, Hjerrild K, Malcolm TR, Vinh NB, Webb CT, Holmes C, MacRaild CA, Chernih HC, Suen WW, Counihan NA, Creek DJ, Scammells PJ, McGowan S, de Koning-Ward TF. Edgar RCS, et al. Among authors: webb ct. Elife. 2022 Sep 13;11:e80813. doi: 10.7554/eLife.80813. Elife. 2022. PMID: 36097817 Free PMC article.

4

Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.

Calic PPS, Vinh NB, Webb CT, Malcolm TR, Ngo A, Lowes K, Drinkwater N, McGowan S, Scammells PJ. Calic PPS, et al. Among authors: webb ct. Eur J Med Chem. 2023 Feb 15;248:115051. doi: 10.1016/j.ejmech.2022.115051. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36634455

5

X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2.

Marijanovic EM, Weronika Swiderska K, Andersen J, Aschenbrenner JC, Webb CT, Drag M, Drinkwater N, McGowan S. Marijanovic EM, et al. Among authors: webb ct. Biochem J. 2020 Oct 16;477(19):3819-3832. doi: 10.1042/BCJ20200569. Biochem J. 2020. PMID: 32926129 Free PMC article.

6

A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.

Webb CT, Yang W, Riley BT, Hayes BK, Sivaraman KK, Malcolm TR, Harrop S, Atkinson SC, Kass I, Buckle AM, Drinkwater N, McGowan S. Webb CT, et al. J Biol Chem. 2022 Jul;298(7):102119. doi: 10.1016/j.jbc.2022.102119. Epub 2022 Jun 9. J Biol Chem. 2022. PMID: 35691342 Free PMC article.

7

Understanding the structure and function of Plasmodium aminopeptidases to facilitate drug discovery.

Mansouri M, Daware K, Webb CT, McGowan S. Mansouri M, et al. Among authors: webb ct. Curr Opin Struct Biol. 2023 Oct;82:102693. doi: 10.1016/j.sbi.2023.102693. Epub 2023 Aug 30. Curr Opin Struct Biol. 2023. PMID: 37657352 Free article. Review.

8

Dissecting EXP2 sequence requirements for protein export in malaria parasites.

Pitman EL, Counihan NA, Modak JK, Chowdury M, Gilson PR, Webb CT, de Koning-Ward TF. Pitman EL, et al. Among authors: webb ct. Front Cell Infect Microbiol. 2024 Jan 12;13:1332146. doi: 10.3389/fcimb.2023.1332146. eCollection 2023. Front Cell Infect Microbiol. 2024. PMID: 38282616 Free PMC article.

9

Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.

Cun WY, Bate CE, Srikhanta YN, Hutton ML, Webb CT, Revitt-Mills SA, Lyras D, McGowan S, Yu H, Keller PA, Pyne SG. Cun WY, et al. Among authors: webb ct. J Med Chem. 2024 Jan 11;67(1):450-466. doi: 10.1021/acs.jmedchem.3c01662. Epub 2023 Dec 19. J Med Chem. 2024. PMID: 38112278

10

The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp.

Rosas NC, Wilksch J, Barber J, Li J, Wang Y, Sun Z, Rocker A, Webb CT, Perlaza-Jiménez L, Stubenrauch CJ, Dhanasekaran V, Song J, Taiaroa G, Davies M, Strugnell RA, Bao Q, Zhou T, McDonald MJ, Lithgow T. Rosas NC, et al. Among authors: webb ct. Elife. 2023 Jul 6;12:e83107. doi: 10.7554/eLife.83107. Elife. 2023. PMID: 37410078 Free PMC article.

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