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Page 1
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Kane AE, Chellappa K, Schultz MB, Arnold M, Li J, Amorim J, Diener C, Zhu D, Mitchell SJ, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima RT, Mitchell J, Bonkowski MS, de Cabo R, Gibbons SM, Wu LE, Ikeno Y, Baur JA, Rajman L, Sinclair DA. Kane AE, et al. Among authors: baur ja. bioRxiv [Preprint]. 2024 Jun 27:2024.06.21.599604. doi: 10.1101/2024.06.21.599604. bioRxiv. 2024. PMID: 38979132 Free PMC article. Preprint.
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Sołdacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, … See abstract for full author list ➔ Lyu YX, et al. Among authors: baur ja. Aging (Albany NY). 2024 Oct 16;16(20):12955-12976. doi: 10.18632/aging.206135. Epub 2024 Oct 16. Aging (Albany NY). 2024. PMID: 39418098 Free PMC article. Review.
An expert consensus statement on biomarkers of ageing for use in intervention studies.
Perri G, French C, Agostinis-Sobrinho C, Anand A, Antarianto RD, Arai Y, Baur JA, Cauli O, Clivaz-Duc M, Colloca G, Demetriades C, de Lucia C, Di Gessa G, Diniz BS, Dotchin CL, Eaglestone G, Elliott BT, Espeland MA, Ferrucci L, Fisher J, Grammatopoulos DK, Hardiany NS, Hassan-Smith Z, Hastings WJ, Jain S, Joshi PK, Katsila T, Kemp GJ, Khaiyat OA, Lamming DW, Gallegos JL, Madeo F, Maier AB, Martin-Ruiz C, Martins IJ, Mathers JC, Mattin LR, Merchant RA, Moskalev A, Neytchev O, Ni Lochlainn M, Owen CM, Phillips SM, Pratt J, Prokopidis K, Rattray NJW, Rúa-Alonso M, Schomburg L, Scott D, Shyam S, Sillanpää E, Tan MMC, Teh R, Tobin SW, Vila-Chã CJ, Vorluni L, Weber D, Welch A, Wilson D, Wilson T, Zhao T, Philippou E, Korolchuk VI, Shannon OM. Perri G, et al. Among authors: baur ja. J Gerontol A Biol Sci Med Sci. 2024 Dec 21:glae297. doi: 10.1093/gerona/glae297. Online ahead of print. J Gerontol A Biol Sci Med Sci. 2024. PMID: 39708300
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.
Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K. Li S, et al. Among authors: baur ja. Cell Metab. 2024 Nov 14:S1550-4131(24)00403-0. doi: 10.1016/j.cmet.2024.10.007. Online ahead of print. Cell Metab. 2024. PMID: 39561766
Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics.
Doan KV, Luongo TS, Ts'olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA. Doan KV, et al. Among authors: baur ja. Nat Cardiovasc Res. 2024 Oct;3(10):1236-1248. doi: 10.1038/s44161-024-00542-9. Epub 2024 Sep 18. Nat Cardiovasc Res. 2024. PMID: 39294272
NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.
Perry CE, Halawani SM, Mukherjee S, Ngaba LV, Lieu M, Lee WD, Davis JG, Adzika GK, Bebenek AN, Bazianos DD, Chen B, Mercado-Ayon E, Flatley LP, Suryawanshi AP, Ho I, Rabinowitz JD, Serai SD, Biko DM, Tamaroff J, DeDio A, Wade K, Lin KY, Livingston DJ, McCormack SE, Lynch DR, Baur JA. Perry CE, et al. Among authors: baur ja. JCI Insight. 2024 Jul 18;9(16):e177152. doi: 10.1172/jci.insight.177152. JCI Insight. 2024. PMID: 39171530 Free PMC article.
Regulation of and challenges in targeting NAD+ metabolism.
Migaud ME, Ziegler M, Baur JA. Migaud ME, et al. Among authors: baur ja. Nat Rev Mol Cell Biol. 2024 Oct;25(10):822-840. doi: 10.1038/s41580-024-00752-w. Epub 2024 Jul 18. Nat Rev Mol Cell Biol. 2024. PMID: 39026037 Review.
143 results