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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Kane AE, Chellappa K, Schultz MB, Arnold M, Li J, Amorim J, Diener C, Zhu D, Mitchell SJ, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima RT, Mitchell J, Bonkowski MS, de Cabo R, Gibbons SM, Wu LE, Ikeno Y, Baur JA, Rajman L, Sinclair DA. Kane AE, et al. Among authors: griffin p. bioRxiv [Preprint]. 2024 Jun 27:2024.06.21.599604. doi: 10.1101/2024.06.21.599604. bioRxiv. 2024. PMID: 38979132 Free PMC article. Preprint.
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.
Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, Carmody C, Vera DL, Kerepesi C, Ying K, Noren Hooten N, Mitchell JR, Evans MK, Gladyshev VN, Sinclair DA. Griffin PT, et al. Nat Aging. 2024 Feb;4(2):261-274. doi: 10.1038/s43587-023-00555-2. Epub 2024 Jan 10. Nat Aging. 2024. PMID: 38200273 Free PMC article.
Chemically induced reprogramming to reverse cellular aging.
Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Yang JH, et al. Aging (Albany NY). 2023 Jul 12;15(13):5966-5989. doi: 10.18632/aging.204896. Epub 2023 Jul 12. Aging (Albany NY). 2023. PMID: 37437248 Free PMC article.
Loss of epigenetic information as a cause of mammalian aging.
Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Yang JH, et al. Among authors: griffin pt. Cell. 2024 Feb 29;187(5):1312-1313. doi: 10.1016/j.cell.2024.01.049. Cell. 2024. PMID: 38428398 No abstract available.
Safety, tolerability, pharmacokinetics, and antimalarial activity of MMV533: a phase 1a first-in-human, randomised, ascending dose and food effect study, and a phase 1b Plasmodium falciparum volunteer infection study.
Bestgen B, Jones S, Thathy V, Kuemmerle A, Barcelo C, Haouala A, Gossen D, Marx MW, Di Resta I, Szramowska M, Webster RA, Llewellyn S, Ritacco DA, Yeo T, Leroy D, Barber BE, Fidock DA, Griffin P, Lickliter J, Chalon S. Bestgen B, et al. Among authors: griffin p. Lancet Infect Dis. 2024 Dec 18:S1473-3099(24)00664-9. doi: 10.1016/S1473-3099(24)00664-9. Online ahead of print. Lancet Infect Dis. 2024. PMID: 39708824 Free article.
Disagreement on foundational principles of biological aging.
Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A. Gladyshev VN, et al. Among authors: griffin pt. PNAS Nexus. 2024 Dec 3;3(12):pgae499. doi: 10.1093/pnasnexus/pgae499. eCollection 2024 Dec. PNAS Nexus. 2024. PMID: 39660064 Free PMC article.
1,215 results