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Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display.
Bioorg Med Chem. 2024 Aug 1;110:117830. doi: 10.1016/j.bmc.2024.117830. Epub 2024 Jul 6.
Bioorg Med Chem. 2024.
PMID: 38981216
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H.
Ohta A, et al. Among authors: chiyoda a.
J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24.
J Am Chem Soc. 2023.
PMID: 37874670
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Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T.
Tanada M, et al. Among authors: chiyoda a.
J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18.
J Am Chem Soc. 2023.
PMID: 37463267
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Effect on physical fitness of a 10-year physical activity intervention in primary health care settings.
Nakamura PM, Papini CB, Teixeira IP, Chiyoda A, Luciano E, Cordeira KL, Kokubun E.
Nakamura PM, et al. Among authors: chiyoda a.
J Phys Act Health. 2015 Jan;12(1):102-8. doi: 10.1123/jpah.2013-0143. Epub 2014 Feb 5.
J Phys Act Health. 2015.
PMID: 24508780
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