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28 results

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Page 1
Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.
Rousel J, Mergen C, Bergmans ME, Bruijnincx LJ, de Kam ML, Klarenbeek NB, Niemeyer-van der Kolk T, van Doorn MBA, Bouwstra JA, Rissmann R; Next-Generation ImmunoDermatology Consortium (NGID). Rousel J, et al. Among authors: klarenbeek nb. J Lipid Res. 2024 Aug;65(8):100591. doi: 10.1016/j.jlr.2024.100591. Epub 2024 Jul 9. J Lipid Res. 2024. PMID: 38992724 Free PMC article. Clinical Trial.
The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers.
Jodl SJ, Ten Voorde W, Klein S, Wagenfeld A, Zollmann FS, Feldmüller M, Klarenbeek NB, de Bruin DT, Jansen MAA, Rissmann R, Rohde B, Moerland M. Jodl SJ, et al. Among authors: klarenbeek nb. Clin Transl Sci. 2024 Mar;17(3):e13771. doi: 10.1111/cts.13771. Clin Transl Sci. 2024. PMID: 38511583 Free PMC article. Clinical Trial.
Guselkumab induction therapy demonstrates long-lasting efficacy in patients with mild psoriasis, results from a randomized, placebo-controlled exploratory clinical trial.
Rousel J, Bergmans ME, van der Meulen LWJ, Pagan L, de Bruin DT, de Kam ML, Klarenbeek NB, Bouwstra JA, Seyger MMB, van den Reek JMPA, Niemeyer-van der Kolk T, Rissmann R, van Doorn MBA; NGID consortium. Rousel J, et al. Among authors: klarenbeek nb. J Am Acad Dermatol. 2024 Feb;90(2):395-397. doi: 10.1016/j.jaad.2023.09.071. Epub 2023 Oct 5. J Am Acad Dermatol. 2024. PMID: 37804933 Free article. Clinical Trial. No abstract available.
Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model.
Assil S, Buters TP, Hameeteman PW, Hallard C, Treijtel N, Niemeyer-Van der Kolk T, de Kam ML, Florencia EFIII, Prens EP, van Doorn MBA, Rissmann R, Klarenbeek NB, Jansen MAA, Moerland M. Assil S, et al. Among authors: klarenbeek nb. Front Immunol. 2023 Jul 20;14:1197650. doi: 10.3389/fimmu.2023.1197650. eCollection 2023. Front Immunol. 2023. PMID: 37545524 Free PMC article. Clinical Trial.
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.
In 't Veld AE, Grievink HW, van der Plas JL, Eveleens Maarse BC, van Kraaij SJW, Woutman TD, Schoonakker M, Klarenbeek NB, de Kam ML, Kamerling IMC, Jansen MAA, Moerland M. In 't Veld AE, et al. Among authors: klarenbeek nb. Immunol Res. 2023 Aug;71(4):617-627. doi: 10.1007/s12026-023-09367-3. Epub 2023 Feb 22. Immunol Res. 2023. PMID: 36811819 Free PMC article. Clinical Trial.
Administration of an adeno-associated viral vector expressing interferon-β in patients with inflammatory hand arthritis, results of a phase I/II study.
Vrouwe JPM, Meulenberg JJM, Klarenbeek NB, Navas-Cañete A, Reijnierse M, Ruiterkamp G, Bevaart L, Lamers RJ, Kloppenburg M, Nelissen RGHH, Huizinga TWJ, Burggraaf J, Kamerling IMC. Vrouwe JPM, et al. Among authors: klarenbeek nb. Osteoarthritis Cartilage. 2022 Jan;30(1):52-60. doi: 10.1016/j.joca.2021.09.013. Epub 2021 Oct 6. Osteoarthritis Cartilage. 2022. PMID: 34626797 Free article. Clinical Trial.
A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.
Berends CL, Pagan L, van Esdonk MJ, Klarenbeek NB, Bergmann KR, Moerland M, van der Wel V, de Visser SJ, Büller H, de Loos F, de Vries WS, Waals H, de Leede LGJ, Burggraaf J, Kamerling IMC. Berends CL, et al. Among authors: klarenbeek nb. Pharmacol Res Perspect. 2021 Apr;9(2):e00739. doi: 10.1002/prp2.739. Pharmacol Res Perspect. 2021. PMID: 33764642 Free PMC article. Clinical Trial.
Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis.
Kruizinga MD, Birkhoff WAJ, van Esdonk MJ, Klarenbeek NB, Cholewinski T, Nelemans T, Dröge MJ, Cohen AF, Zuiker RGJA. Kruizinga MD, et al. Among authors: klarenbeek nb. Br J Clin Pharmacol. 2020 Jan;86(1):175-181. doi: 10.1111/bcp.14156. Epub 2020 Jan 3. Br J Clin Pharmacol. 2020. PMID: 31658494 Free PMC article.
Heparin-Induced Thrombocytopenia.
Klarenbeek NB, Eikenboom JC. Klarenbeek NB, et al. N Engl J Med. 2015 Nov 5;373(19):1882-3. doi: 10.1056/NEJMc1510993. N Engl J Med. 2015. PMID: 26535526 No abstract available.
28 results