Gorfe AA - Search Results

1

Gorfe AA, Gnanakaran S. Gorfe AA, et al. Curr Opin Struct Biol. 2024 Dec;89:102938. doi: 10.1016/j.sbi.2024.102938. Epub 2024 Oct 4. Curr Opin Struct Biol. 2024. PMID: 39368258 No abstract available.

2

Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors.

Araya MK, Chen W, Ke Y, Zhou Y, Gorfe AA, Hancock JF, Liu J. Araya MK, et al. Among authors: gorfe aa. J Am Chem Soc. 2024 Jul 24;146(29):19782-19791. doi: 10.1021/jacs.4c02183. Epub 2024 Jul 13. J Am Chem Soc. 2024. PMID: 39001846 Free PMC article.

3

From disorder comes function: Regulation of small GTPase function by intrinsically disordered lipidated membrane anchor.

Hutchins CM, Gorfe AA. Hutchins CM, et al. Among authors: gorfe aa. Curr Opin Struct Biol. 2024 Aug;87:102869. doi: 10.1016/j.sbi.2024.102869. Epub 2024 Jun 28. Curr Opin Struct Biol. 2024. PMID: 38943706 Free PMC article. Review.

4

Intrinsically Disordered Membrane Anchors of Rheb, RhoA, and DiRas3 Small GTPases: Molecular Dynamics, Membrane Organization, and Interactions.

Hutchins CM, Gorfe AA. Hutchins CM, et al. Among authors: gorfe aa. J Phys Chem B. 2024 Jul 11;128(27):6518-6528. doi: 10.1021/acs.jpcb.4c01876. Epub 2024 Jun 28. J Phys Chem B. 2024. PMID: 38942776 Free PMC article.

5

Intrinsically disordered membrane anchors of Rheb, RhoA and DiRas3 small GTPases: Molecular dynamics, membrane organization, and interactions.

Hutchins CM, Gorfe AA. Hutchins CM, et al. Among authors: gorfe aa. bioRxiv [Preprint]. 2024 Apr 28:2024.04.25.591151. doi: 10.1101/2024.04.25.591151. bioRxiv. 2024. Update in: J Phys Chem B. 2024 Jul 11;128(27):6518-6528. doi: 10.1021/acs.jpcb.4c01876 PMID: 38712287 Free PMC article. Updated. Preprint.

6

Biophysical and Biochemical Characterization of Structurally Diverse Small Molecule Hits for KRAS Inhibition.

Pagba CV, Gupta AK, Dilsha K, Sadrpour P, Jakubec J, Prakash P, van der Hoeven D, Cho KJ, Gilbertson S, Gorfe AA. Pagba CV, et al. Among authors: gorfe aa. Chembiochem. 2024 Apr 2;25(7):e202300827. doi: 10.1002/cbic.202300827. Epub 2024 Mar 7. Chembiochem. 2024. PMID: 38349283

7

Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases.

Araya MK, Gorfe AA. Araya MK, et al. Among authors: gorfe aa. Commun Biol. 2023 Nov 2;6(1):1111. doi: 10.1038/s42003-023-05487-6. Commun Biol. 2023. PMID: 37919400 Free PMC article.

8

Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function.

Liang X, Jung SY, Fong LW, Bildik G, Gray JP, Mao W, Zhang S, Millward SW, Gorfe AA, Zhou Y, Lu Z, Bast RC Jr. Liang X, et al. Among authors: gorfe aa. iScience. 2023 Oct 6;26(11):108151. doi: 10.1016/j.isci.2023.108151. eCollection 2023 Nov 17. iScience. 2023. PMID: 37915607 Free PMC article.

9

A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95.

Rehl KM, Selvakumar J, Pitsch RL, Hoang D, Arumugam K, Harshman SW, Gorfe AA, Cho KJ. Rehl KM, et al. Among authors: gorfe aa. Life Sci Alliance. 2023 Sep 4;6(11):e202302094. doi: 10.26508/lsa.202302094. Print 2023 Nov. Life Sci Alliance. 2023. PMID: 37666666 Free PMC article.

10

Small-Molecule Inhibition of KRAS through Conformational Selection.

Pagba CV, Gupta AK, Gorfe AA. Pagba CV, et al. Among authors: gorfe aa. ACS Omega. 2023 Aug 18;8(34):31419-31426. doi: 10.1021/acsomega.3c04013. eCollection 2023 Aug 29. ACS Omega. 2023. PMID: 37663463 Free PMC article.

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