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A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL.
Gebing P, Loizou S, Hänsch S, Schliehe-Diecks J, Spory L, Stachura P, Jepsen VH, Vogt M, Pandyra AA, Wang H, Zhuang Z, Zimmermann J, Schrappe M, Cario G, Alsadeq A, Schewe DM, Borkhardt A, Lenk L, Fischer U, Bhatia S. Gebing P, et al. Among authors: alsadeq a. Blood Adv. 2024 Oct 8;8(19):4997-5011. doi: 10.1182/bloodadvances.2023011145. Blood Adv. 2024. PMID: 39008716 Free PMC article.
AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL.
Spory L, Zimmermann J, Vossen-Gajcy M, Beder T, Bastian L, Alsadeq A, Winterberg D, Vogiatzi F, Wirbelauer T, Bhat H, Borkhardt A, Bhatia S, Schrappe M, Cario G, Schewe DM, Lenk L. Spory L, et al. Among authors: alsadeq a. Hemasphere. 2023 Sep 1;7(9):e945. doi: 10.1097/HS9.0000000000000945. eCollection 2023 Sep. Hemasphere. 2023. PMID: 37670804 Free PMC article. No abstract available.
Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.
Lenk L, Winterberg D, Vogiatzi F, Laqua A, Spory L, Mayar A, Dietterle A, Münch G, Vokuhl C, Richter J, Polson AG, Schüler T, Kahlert UD, Peipp M, Valerius T, Schrappe M, Cario G, Jumaa H, Hobeika E, Brüggemann M, Alsadeq A, Schewe DM. Lenk L, et al. Among authors: alsadeq a. Hemasphere. 2022 Jul 15;6(8):e754. doi: 10.1097/HS9.0000000000000754. eCollection 2022 Aug. Hemasphere. 2022. PMID: 35935606 Free PMC article. No abstract available.
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells.
Vadakumchery A, Faraidun H, Ayoubi OE, Outaleb I, Schmid V, Abdelrasoul H, Amendt T, Khadour A, Setz C, Göhring K, Lodd K, Hitzing C, Alkhatib A, Bilal M, Benckendorff J, Al Shugri AK, Brakebusch CH, Engels N, Datta M, Hobeika E, Alsadeq A, Jumaa H. Vadakumchery A, et al. Among authors: alsadeq a. Front Immunol. 2022 Mar 15;13:842340. doi: 10.3389/fimmu.2022.842340. eCollection 2022. Front Immunol. 2022. PMID: 35371049 Free PMC article.
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Lenk L, Carlet M, Vogiatzi F, Spory L, Winterberg D, Cousins A, Vossen-Gajcy M, Ibruli O, Vokuhl C, Cario G, El Ayoubi O, Kramer L, Ritgen M, Brüggemann M, Häsler R, Schrappe M, Fuhrmann S, Halsey C, Jeremias I, Hobeika E, Jumaa H, Alsadeq A, Schewe DM. Lenk L, et al. Among authors: alsadeq a. Commun Biol. 2021 Jan 15;4(1):73. doi: 10.1038/s42003-020-01591-z. Commun Biol. 2021. PMID: 33452446 Free PMC article.
Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Abdelrasoul H, Vadakumchery A, Werner M, Lenk L, Khadour A, Young M, El Ayoubi O, Vogiatzi F, Krämer M, Schmid V, Chen Z, Yousafzai Y, Cario G, Schrappe M, Müschen M, Halsey C, Mulaw MA, Schewe DM, Hobeika E, Alsadeq A, Jumaa H. Abdelrasoul H, et al. Among authors: alsadeq a. Nat Commun. 2020 Jun 24;11(1):3194. doi: 10.1038/s41467-020-16927-w. Nat Commun. 2020. PMID: 32581241 Free PMC article.
IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia.
Alsadeq A, Lenk L, Vadakumchery A, Cousins A, Vokuhl C, Khadour A, Vogiatzi F, Seyfried F, Meyer LH, Cario G, Hobeika E, Debatin KM, Halsey C, Schrappe M, Schewe DM, Jumaa H. Alsadeq A, et al. Blood. 2018 Oct 11;132(15):1614-1617. doi: 10.1182/blood-2018-04-844209. Epub 2018 Aug 28. Blood. 2018. PMID: 30154115 Free PMC article. No abstract available.
23 results