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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Widjaja AA, Lim WW, Viswanathan S, Chothani S, Corden B, Dasan CM, Goh JWT, Lim R, Singh BK, Tan J, Pua CJ, Lim SY, Adami E, Schafer S, George BL, Sweeney M, Xie C, Tripathi M, Sims NA, Hübner N, Petretto E, Withers DJ, Ho L, Gil J, Carling D, Cook SA. Widjaja AA, et al. Among authors: gil j. Nature. 2024 Aug;632(8023):157-165. doi: 10.1038/s41586-024-07701-9. Epub 2024 Jul 17. Nature. 2024. PMID: 39020175 Free PMC article.
Ageing: Out with the old.
Gil J, Withers DJ. Gil J, et al. Nature. 2016 Feb 11;530(7589):164-5. doi: 10.1038/nature16875. Epub 2016 Feb 3. Nature. 2016. PMID: 26840486 Free PMC article. No abstract available.
Cardiac glycosides are broad-spectrum senolytics.
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J. Guerrero A, et al. Among authors: gil j. Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21. Nat Metab. 2019. PMID: 31799499 Free PMC article.
Galactose-modified duocarmycin prodrugs as senolytics.
Guerrero A, Guiho R, Herranz N, Uren A, Withers DJ, Martínez-Barbera JP, Tietze LF, Gil J. Guerrero A, et al. Among authors: gil j. Aging Cell. 2020 Apr;19(4):e13133. doi: 10.1111/acel.13133. Epub 2020 Mar 16. Aging Cell. 2020. PMID: 32175667 Free PMC article.
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells.
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, Martínez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J. McHugh D, et al. Among authors: gil j. Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27. Nat Cell Biol. 2023. PMID: 38012402 Free PMC article.
Detection of senescence using machine learning algorithms based on nuclear features.
Duran I, Pombo J, Sun B, Gallage S, Kudo H, McHugh D, Bousset L, Barragan Avila JE, Forlano R, Manousou P, Heikenwalder M, Withers DJ, Vernia S, Goldin RD, Gil J. Duran I, et al. Among authors: gil j. Nat Commun. 2024 Feb 3;15(1):1041. doi: 10.1038/s41467-024-45421-w. Nat Commun. 2024. PMID: 38310113 Free PMC article.
Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. Herranz N, et al. Among authors: gil j. Nat Cell Biol. 2024 Jun;26(6):1019. doi: 10.1038/s41556-024-01443-6. Nat Cell Biol. 2024. PMID: 38778130 No abstract available.
Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.
Gallage S, Irvine EE, Barragan Avila JE, Reen V, Pedroni SMA, Duran I, Ranvir V, Khadayate S, Pombo J, Brookes S, Heide D, Dharmalingham G, Choudhury AI, Singh I, Herranz N, Vernia S, Heikenwalder M, Gil J, Withers DJ. Gallage S, et al. Among authors: gil j. Nat Aging. 2024 Nov;4(11):1544-1561. doi: 10.1038/s43587-024-00695-z. Epub 2024 Aug 29. Nat Aging. 2024. PMID: 39210150 Free PMC article.
2,166 results