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Expression of the plasma membrane citrate carrier (pmCiC) in human cancerous tissues-correlation with tumour aggressiveness.
Schwertner B, Dahdal G, Jagla W, Grossmann L, Drexler K, Krahn MP, Evert K, Berneburg M, Haferkamp S, Ziegler C, Parkinson EK, Zahn G, Mycielska ME, Gaumann A. Schwertner B, et al. Among authors: jagla w. Front Cell Dev Biol. 2024 Jul 3;12:1308135. doi: 10.3389/fcell.2024.1308135. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39022761 Free PMC article.
Cancer-associated cells release citrate to support tumour metastatic progression.
Drexler K, Schmidt KM, Jordan K, Federlin M, Milenkovic VM, Liebisch G, Artati A, Schmidl C, Madej G, Tokarz J, Cecil A, Jagla W, Haerteis S, Aung T, Wagner C, Kolodziejczyk M, Heinke S, Stanton EH, Schwertner B, Riegel D, Wetzel CH, Buchalla W, Proescholdt M, Klein CA, Berneburg M, Schlitt HJ, Brabletz T, Ziegler C, Parkinson EK, Gaumann A, Geissler EK, Adamski J, Haferkamp S, Mycielska ME. Drexler K, et al. Among authors: jagla w. Life Sci Alliance. 2021 Mar 23;4(6):e202000903. doi: 10.26508/lsa.202000903. Print 2021 Jun. Life Sci Alliance. 2021. PMID: 33758075 Free PMC article.
Extracellular Citrate Affects Critical Elements of Cancer Cell Metabolism and Supports Cancer Development In Vivo.
Mycielska ME, Dettmer K, Rümmele P, Schmidt K, Prehn C, Milenkovic VM, Jagla W, Madej GM, Lantow M, Schladt M, Cecil A, Koehl GE, Eggenhofer E, Wachsmuth CJ, Ganapathy V, Schlitt HJ, Kunzelmann K, Ziegler C, Wetzel CH, Gaumann A, Lang SA, Adamski J, Oefner PJ, Geissler EK. Mycielska ME, et al. Among authors: jagla w. Cancer Res. 2018 May 15;78(10):2513-2523. doi: 10.1158/0008-5472.CAN-17-2959. Epub 2018 Mar 6. Cancer Res. 2018. PMID: 29510993
Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects.
Albert V, Piendl G, Yousseff D, Lammert H, Hummel M, Ortmann O, Jagla W, Gaumann A, Wege AK, Brockhoff G. Albert V, et al. Among authors: jagla w. Arch Gynecol Obstet. 2022 Oct;306(4):1197-1210. doi: 10.1007/s00404-022-06434-2. Epub 2022 Mar 17. Arch Gynecol Obstet. 2022. PMID: 35298675 Free PMC article.
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.
Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS. Nussbaum JM, et al. Among authors: jagla w. Nature. 2012 May 2;485(7400):651-5. doi: 10.1038/nature11060. Nature. 2012. PMID: 22660329 Free PMC article.
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. Alexandru A, et al. Among authors: jagla w. J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011. J Neurosci. 2011. PMID: 21900558 Free PMC article.
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: jagla w. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.
30 results