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iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, Temple S, Arkin MR, Grinberg LT. Theofilas P, et al. Among authors: arkin mr. Mol Cell Neurosci. 2024 Sep;130:103954. doi: 10.1016/j.mcn.2024.103954. Epub 2024 Jul 20. Mol Cell Neurosci. 2024. PMID: 39032719
[No title available]
[No authors listed] [No authors listed] PMID: 39303694
Deep phenotypic profiling of neuroactive drugs in larval zebrafish.
Gendelev L, Taylor J, Myers-Turnbull D, Chen S, McCarroll MN, Arkin MR, Kokel D, Keiser MJ. Gendelev L, et al. Among authors: arkin mr. Nat Commun. 2024 Nov 17;15(1):9955. doi: 10.1038/s41467-024-54375-y. Nat Commun. 2024. PMID: 39551797 Free PMC article.
Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.
Chou J, Robinson TM, Egusa EA, Lodha R, Zhang M, Badura M, Mikayelyan M, Delavan HM, Swinderman J, Wilson C, Zhu J, Das R, Nguyen M, Loehr A, Golsorkhi T, Simmons A, Abida W, Chinnaiyan AM, Arkin MR, Small EJ, Quigley DA, Yang L, Kim M, Ashworth A, Feng FY. Chou J, et al. Among authors: arkin mr. Clin Cancer Res. 2024 Dec 2;30(23):5445-5458. doi: 10.1158/1078-0432.CCR-23-3785. Clin Cancer Res. 2024. PMID: 39321214
116 results