Yaffe MB - Search Results

1

Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas.

Chiappa M, Decio A, Guarrera L, Mengoli I, Karki A, Yemane D, Ghilardi C, Scanziani E, Canesi S, Barbera MC, Craparotta I, Bolis M, Fruscio R, Grasselli C, Ceruti T, Zucchetti M, Patterson JC, Lu RA, Yaffe MB, Ridinger M, Damia G, Guffanti F. Chiappa M, et al. Among authors: yaffe mb. Cell Death Dis. 2024 Jul 22;15(7):521. doi: 10.1038/s41419-024-06894-1. Cell Death Dis. 2024. PMID: 39039067 Free PMC article.

2

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. Elia AE, et al. Among authors: yaffe mb. Cell. 2003 Oct 3;115(1):83-95. doi: 10.1016/s0092-8674(03)00725-6. Cell. 2003. PMID: 14532005 Free article.

3

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB. Manke IA, et al. Among authors: yaffe mb. Mol Cell. 2005 Jan 7;17(1):37-48. doi: 10.1016/j.molcel.2004.11.021. Mol Cell. 2005. PMID: 15629715 Free article.

4

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.

Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. Reinhardt HC, et al. Among authors: yaffe mb. Cancer Cell. 2007 Feb;11(2):175-89. doi: 10.1016/j.ccr.2006.11.024. Cancer Cell. 2007. PMID: 17292828 Free PMC article.

5

Exploiting synthetic lethal interactions for targeted cancer therapy.

Reinhardt HC, Jiang H, Hemann MT, Yaffe MB. Reinhardt HC, et al. Among authors: yaffe mb. Cell Cycle. 2009 Oct 1;8(19):3112-9. doi: 10.4161/cc.8.19.9626. Cell Cycle. 2009. PMID: 19755856 Free PMC article. Review.

6

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB. van Vugt MA, et al. Among authors: yaffe mb. PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287. PLoS Biol. 2010. PMID: 20126263 Free PMC article.

7

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB. Reinhardt HC, et al. Among authors: yaffe mb. Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018. Mol Cell. 2010. PMID: 20932473 Free PMC article.

8

Fixin' to divide.

Mohammad DH, Yaffe MB. Mohammad DH, et al. Among authors: yaffe mb. Mol Cell. 2012 Feb 10;45(3):273-5. doi: 10.1016/j.molcel.2012.01.022. Mol Cell. 2012. PMID: 22325348 Free PMC article.

9

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Lee MJ, et al. Among authors: yaffe mb. Cell. 2012 May 11;149(4):780-94. doi: 10.1016/j.cell.2012.03.031. Cell. 2012. PMID: 22579283 Free PMC article.

10

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. Morandell S, et al. Among authors: yaffe mb. Cell Rep. 2013 Nov 27;5(4):868-77. doi: 10.1016/j.celrep.2013.10.025. Epub 2013 Nov 14. Cell Rep. 2013. PMID: 24239348 Free PMC article.

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