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Page 1
Arsenic Compromises Both p97 and Proteasome Functions.
Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E. Tillotson J, et al. Among authors: ambrose aj. Chem Res Toxicol. 2017 Jul 17;30(7):1508-1514. doi: 10.1021/acs.chemrestox.7b00158. Epub 2017 Jul 7. Chem Res Toxicol. 2017. PMID: 28636814 Free PMC article.
Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL.
Sivinski J, Ambrose AJ, Panfilenko I, Zerio CJ, Machulis JM, Mollasalehi N, Kaneko LK, Stevens M, Ray AM, Park Y, Wu C, Hoang QQ, Johnson SM, Chapman E. Sivinski J, et al. Among authors: ambrose aj. mBio. 2021 Jan 12;12(1):e02167-20. doi: 10.1128/mBio.02167-20. mBio. 2021. PMID: 33436430 Free PMC article.
Allosteric differences dictate GroEL complementation of E. coli.
Sivinski J, Ngo D, Zerio CJ, Ambrose AJ, Watson ER, Kaneko LK, Kostelic MM, Stevens M, Ray AM, Park Y, Wu C, Marty MT, Hoang QQ, Zhang DD, Lander GC, Johnson SM, Chapman E. Sivinski J, et al. Among authors: ambrose aj. FASEB J. 2022 Mar;36(3):e22198. doi: 10.1096/fj.202101708RR. FASEB J. 2022. PMID: 35199390 Free PMC article.
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM. Abdeen S, et al. Among authors: ambrose aj. J Med Chem. 2018 Aug 23;61(16):7345-7357. doi: 10.1021/acs.jmedchem.8b00989. Epub 2018 Aug 14. J Med Chem. 2018. PMID: 30060666 Free PMC article.
Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. J Med Chem. 2023 Jan 12;66(1):677-694. doi: 10.1021/acs.jmedchem.2c01631. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36516003
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.
Ambrose AJ, Zerio CJ, Sivinski J, Zhu X, Godek J, Sanchez JL, Khanna M, Khanna R, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. Biochemistry. 2024 Feb 6;63(3):251-263. doi: 10.1021/acs.biochem.3c00531. Epub 2024 Jan 20. Biochemistry. 2024. PMID: 38243804
43 results