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Page 1
A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Münzker L, Kimani SW, Fowkes MM, Dong A, Zheng H, Li Y, Dasovich M, Zak KM, Leung AKL, Elkins JM, Kessler D, Arrowsmith CH, Halabelian L, Böttcher J. Münzker L, et al. Among authors: dasovich m. Commun Biol. 2024 Jul 24;7(1):901. doi: 10.1038/s42003-024-06584-w. Commun Biol. 2024. PMID: 39048679 Free PMC article.
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.
Sang CC, Moore G, Tereshchenko M, Nosella ML, Zhang H, Alderson TR, Dasovich M, Leung A, Finkelstein IJ, Forman-Kay JD, Lee HO. Sang CC, et al. Among authors: dasovich m. bioRxiv [Preprint]. 2024 Jan 22:2024.01.20.575817. doi: 10.1101/2024.01.20.575817. bioRxiv. 2024. Update in: EMBO Rep. 2024 Dec;25(12):5635-5666. doi: 10.1038/s44319-024-00285-5 PMID: 38328070 Free PMC article. Updated. Preprint.
Poly ADP-ribose signaling is dysregulated in Huntington disease.
Maiuri T, Bazan CB, Harding RJ, Begeja N, Kam TI, Byrne LM, Rodrigues FB, Warner MM, Neuman K, Mansoor M, Badiee M, Dasovich M, Wang K, Thompson LM, Leung AKL, Andres SN, Wild EJ, Dawson TM, Dawson VL, Arrowsmith CH, Truant R. Maiuri T, et al. Among authors: dasovich m. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2318098121. doi: 10.1073/pnas.2318098121. Epub 2024 Sep 27. Proc Natl Acad Sci U S A. 2024. PMID: 39331414
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini.
Richardson BC, Turlington ZR, Vaz Ferreira de Macedo S, Phillips SK, Perry K, Brancato SG, Cooke EW, Gwilt JR, Dasovich MA, Roering AJ, Rossi FM, Snider MJ, French JB, Hicks KA. Richardson BC, et al. Among authors: dasovich ma. Biochemistry. 2024 Oct 1;63(19):2506-2516. doi: 10.1021/acs.biochem.4c00306. Epub 2024 Sep 12. Biochemistry. 2024. PMID: 39265075
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K. Gao J, et al. Among authors: dasovich m. Sci Transl Med. 2022 Sep 14;14(662):eabq3215. doi: 10.1126/scitranslmed.abq3215. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103513 Free PMC article.
Poly(ADP-ribose) drives condensation of FUS via a transient interaction.
Rhine K, Dasovich M, Yoniles J, Badiee M, Skanchy S, Ganser LR, Ge Y, Fare CM, Shorter J, Leung AKL, Myong S. Rhine K, et al. Among authors: dasovich m. Mol Cell. 2022 Mar 3;82(5):969-985.e11. doi: 10.1016/j.molcel.2022.01.018. Epub 2022 Feb 18. Mol Cell. 2022. PMID: 35182479 Free PMC article.
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