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Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy.
Angelopoulou A, Theocharous G, Valakos D, Polyzou A, Magkouta S, Myrianthopoulos V, Havaki S, Fiorillo M, Tremi I, Vachlas K, Nisotakis T, Thanos DF, Pantazaki A, Kletsas D, Bartek J, Petty R, Thanos D, McCrimmon RJ, Papaspyropoulos A, Gorgoulis VG. Angelopoulou A, et al. Mol Cancer. 2024 Jul 25;23(1):147. doi: 10.1186/s12943-024-02061-4. Mol Cancer. 2024. PMID: 39048991 Free PMC article.
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gál Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, Gorgoulis VG. Zampetidis CP, et al. Among authors: angelopoulou a. Mol Cell. 2021 Dec 2;81(23):4907-4923.e8. doi: 10.1016/j.molcel.2021.10.017. Epub 2021 Nov 17. Mol Cell. 2021. PMID: 34793711 Free article.
RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1.
Papaspyropoulos A, Angelopoulou A, Mourkioti I, Polyzou A, Pankova D, Toskas K, Lanfredini S, Pantazaki AA, Lagopati N, Kotsinas A, Evangelou K, Chronopoulos E, O'Neill E, Gorgoulis V. Papaspyropoulos A, et al. Among authors: angelopoulou a. EMBO Rep. 2022 Feb 3;23(2):e51287. doi: 10.15252/embr.202051287. Epub 2021 Dec 13. EMBO Rep. 2022. PMID: 34897944 Free PMC article.
Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide.
Anastasiou IA, Eleftheriadou I, Tentolouris A, Sarantis P, Angelopoulou A, Katsaouni A, Mourouzis I, Karamouzis MV, Gorgoulis V, Pantos C, Tentolouris N. Anastasiou IA, et al. Among authors: angelopoulou a. J Biochem Mol Toxicol. 2022 Aug;36(8):e23099. doi: 10.1002/jbt.23099. Epub 2022 May 20. J Biochem Mol Toxicol. 2022. PMID: 35593412
60 results