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Page 1
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia.
Kim-Muller JY, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, Joaquim S, Stansfield JC, Zhang J, Robertson A, Pang J, Opsahl A, Boucher M, Breen D, Hales K, Sheikh A, Wu Z, Zhang BB. Kim-Muller JY, et al. Among authors: pashos e. Cell Rep. 2023 Jan 31;42(1):111947. doi: 10.1016/j.celrep.2022.111947. Epub 2023 Jan 10. Cell Rep. 2023. PMID: 36640326 Free article.
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Flaherty SE 3rd, Bezy O, Zheng W, Yan D, Li X, Jagarlapudi S, Albuquerque B, Esquejo RM, Peloquin M, Semache M, Mancini A, Kang L, Drujan D, Breitkopf SB, Griffin JD, Jean Beltran PM, Xue L, Stansfield J, Pashos E, Shakey Q, Pehmøller C, Monetti M, Birnbaum MJ, Fortin JP, Wu Z. Flaherty SE 3rd, et al. Among authors: pashos e. Nat Commun. 2023 Jul 4;14(1):3953. doi: 10.1038/s41467-023-39597-w. Nat Commun. 2023. PMID: 37402735 Free PMC article.
Cancer Cachexia in STK11/LKB1 -mutated NSCLC is Dependent on Tumor-secreted GDF15.
Yu J, Guo T, Gupta A, Llano EM, Wajahat N, Slater S, Deng Q, Akbay EA, Shelton JM, Evers BM, Wu Z, Tzameli I, Pashos E, Minna JD, Iyengar P, Infante RE. Yu J, et al. Among authors: pashos e. bioRxiv [Preprint]. 2024 Jun 17:2024.06.14.598891. doi: 10.1101/2024.06.14.598891. bioRxiv. 2024. PMID: 38948776 Free PMC article. Preprint.
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice.
Lee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul PW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. Lee S, et al. Among authors: pashos e. Nat Cardiovasc Res. 2023 May;2(5):438-448. doi: 10.1038/s44161-023-00266-2. Epub 2023 May 11. Nat Cardiovasc Res. 2023. PMID: 39196046 Free PMC article.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Among authors: pashos e. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.
Gill D, Arvanitis M, Carter P, Hernández Cordero AI, Jo B, Karhunen V, Larsson SC, Li X, Lockhart SM, Mason A, Pashos E, Saha A, Tan VY, Zuber V, Bossé Y, Fahle S, Hao K, Jiang T, Joubert P, Lunt AC, Ouwehand WH, Roberts DJ, Timens W, van den Berge M, Watkins NA, Battle A, Butterworth AS, Danesh J, Di Angelantonio E, Engelhardt BE, Peters JE, Sin DD, Burgess S. Gill D, et al. Among authors: pashos e. R Soc Open Sci. 2020 Nov 18;7(11):200958. doi: 10.1098/rsos.200958. eCollection 2020 Nov. R Soc Open Sci. 2020. PMID: 33391794 Free PMC article.
Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.
Liu Y, Conlon DM, Bi X, Slovik KJ, Shi J, Edelstein HI, Millar JS, Javaheri A, Cuchel M, Pashos EE, Iqbal J, Hussain MM, Hegele RA, Yang W, Duncan SA, Rader DJ, Morrisey EE. Liu Y, et al. Among authors: pashos ee. Cell Rep. 2017 May 16;19(7):1456-1466. doi: 10.1016/j.celrep.2017.04.064. Cell Rep. 2017. PMID: 28514664 Free PMC article.
17 results