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GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia.
Kim-Muller JY, Song L, LaCarubba Paulhus B, Pashos E, Li X, Rinaldi A, Joaquim S, Stansfield JC, Zhang J, Robertson A, Pang J, Opsahl A, Boucher M, Breen D, Hales K, Sheikh A, Wu Z, Zhang BB. Kim-Muller JY, et al. Among authors: wu z. Cell Rep. 2023 Jan 31;42(1):111947. doi: 10.1016/j.celrep.2022.111947. Epub 2023 Jan 10. Cell Rep. 2023. PMID: 36640326 Free article.
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Flaherty SE 3rd, Bezy O, Zheng W, Yan D, Li X, Jagarlapudi S, Albuquerque B, Esquejo RM, Peloquin M, Semache M, Mancini A, Kang L, Drujan D, Breitkopf SB, Griffin JD, Jean Beltran PM, Xue L, Stansfield J, Pashos E, Shakey Q, Pehmøller C, Monetti M, Birnbaum MJ, Fortin JP, Wu Z. Flaherty SE 3rd, et al. Among authors: wu z. Nat Commun. 2023 Jul 4;14(1):3953. doi: 10.1038/s41467-023-39597-w. Nat Commun. 2023. PMID: 37402735 Free PMC article.
Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
Breen DM, Jagarlapudi S, Patel A, Zou C, Joaquim S, Li X, Kang L, Pang J, Hales K, Ziso-Qejvanaj E, Vera NB, Bennett D, He T, Lambert M, Kelleher K, Wu Z, Zhang BB, Lin L, Seeley RJ, Bezy O. Breen DM, et al. Among authors: wu z. iScience. 2021 May 19;24(6):102554. doi: 10.1016/j.isci.2021.102554. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189431 Free PMC article.
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates.
Breen DM, Kim H, Bennett D, Calle RA, Collins S, Esquejo RM, He T, Joaquim S, Joyce A, Lambert M, Lin L, Pettersen B, Qiao S, Rossulek M, Weber G, Wu Z, Zhang BB, Birnbaum MJ. Breen DM, et al. Among authors: wu z. Cell Metab. 2020 Dec 1;32(6):938-950.e6. doi: 10.1016/j.cmet.2020.10.023. Epub 2020 Nov 17. Cell Metab. 2020. PMID: 33207247 Free article.
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation.
Fung E, Kang L, Sapashnik D, Benard S, Sievers A, Liu Y, Yan G, Zhou J, Rodriguez L, Ma W, Stochaj WR, LaVallie E, Wroblewska L, Kelleher K, Tam A, Bezy O, Breen D, Chabot JR, He T, Lin L, Wu Z, Mosyak L. Fung E, et al. Among authors: wu z. Sci Rep. 2021 Apr 26;11(1):8921. doi: 10.1038/s41598-021-87959-5. Sci Rep. 2021. PMID: 33903632 Free PMC article.
Cancer Cachexia in STK11/LKB1 -mutated NSCLC is Dependent on Tumor-secreted GDF15.
Yu J, Guo T, Gupta A, Llano EM, Wajahat N, Slater S, Deng Q, Akbay EA, Shelton JM, Evers BM, Wu Z, Tzameli I, Pashos E, Minna JD, Iyengar P, Infante RE. Yu J, et al. Among authors: wu z. bioRxiv [Preprint]. 2024 Jun 17:2024.06.14.598891. doi: 10.1101/2024.06.14.598891. bioRxiv. 2024. PMID: 38948776 Free PMC article. Preprint.
Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model.
Bernardo B, Joaquim S, Garren J, Boucher M, Houle C, LaCarubba B, Qiao S, Wu Z, Esquejo RM, Peloquin M, Kim H, Breen DM. Bernardo B, et al. Among authors: wu z. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1813-1829. doi: 10.1002/jcsm.12618. Epub 2020 Sep 13. J Cachexia Sarcopenia Muscle. 2020. PMID: 32924335 Free PMC article.
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